Recombinant Mouse IL-4R alpha Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interleukin 4 Receptor alpha (IL-4 R alpha ), also known as CD124 and BSF receptor, is a widely expressed 140 kDa transmembrane glycoprotein in the class I cytokine receptor family. IL-4 R alpha plays an important role in Th2-biased immune responses, alternative macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherogenesis (1 ‑ 5). Mature mouse IL-4 R alpha consists of a 208 amino acid (aa) extracellular domain (ECD) that contains a ligand binding region and one fibronectin type-III domain, a 24 aa transmembrane segment, and a 553 aa cytoplasmic domain that contains one Box 1 motif and one ITIM motif (6). Within the ECD, mouse IL-4 R alpha shares 51% and 76% aa sequence identity with human and rat IL-4 R alpha , respectively. Alternate splicing of mouse IL-4 R alpha generates a secreted isoform and an isoform that lacks the cytoplasmic region (6 - 8). Proteolytic cleavage can also release soluble IL-4 R alpha , and both these mechanisms produce a molecule which retains ligand binding properties and inhibits IL-4 bioactivity (6, 7, 9). IL-4 R alpha is a component of two distinct receptor complexes and shows species selectivity between human and mouse (10). It can associate with the common gamma chain ( gamma c) to form the IL-4 responsive type I receptor in which gamma c increases the affinity for IL-4 and enables signaling (11, 12). It can alternatively associate with IL-13 R alpha 1 to form the type II receptor which is responsive to both IL-4 and IL-13 (13, 14). The use of shared receptor components contributes to the overlapping biological effects of IL-4 and IL-13 as well as other cytokines that utilize gamma c (i.e. IL-2, IL-7, IL-9, IL-15, and IL-21) (15, 16).

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 3 applications: ELISA, In Vivo, Surface Plasmon Resonance.

Showing Publications 1 - 2 of 2.

Publications using 530-MR	Applications	Species
GR Diogo, A Sparrow, MJ Paul, A Copland, PJ Hart, S Stelter, C van Dollew, PMW Drake, DC Macallan, R Reljic Murine IL-4?2 splice variant down-regulates IL-4 activities independently of IL-4R? binding and STAT-6 phosphorylation Cytokine, 2017-09-13;99(0):154-162. 2017-09-13 [PMID: 28917204] (ELISA, Surface Plasmon Resonance, Mouse)	ELISA, Surface Plasmon Resonance	Mouse
Venmar K, Carter K, Hwang D, Dozier E, Fingleton B IL4 receptor ILR4alpha regulates metastatic colonization by mammary tumors through multiple signaling pathways. Cancer Res, 2014-06-19;74(16):4329-40. 2014-06-19 [PMID: 24947041] (In Vivo, Mouse)	In Vivo	Mouse

Array 530-MR

• IL-4R alpha Antibodies
• IL-4R alpha ELISA Kits
• IL-4R alpha Lysate
• IL-4R alpha Proteins
• IL-4R alpha Proteins and Enzymes