Recombinant Human Neurocan Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Neurocan, also known as CSPG3 and 1D1, is a secreted chondroitin sulfate proteoglycan that is primarily expressed in the central nervous system (1). Human Neurocan contains one Ig-like V-type domain, two Link domains, two EGF-like domains, one C-type lectin-like domain, and one Sushi domain (2). It is an approximately 300 kDa molecule of which 66 kDa is chondroitin sulfate and 60 kDa is N‑ and O‑linked glycosylation (3). Mature human Neurocan shares 66% aa sequence identity with mature mouse and rat Neurocan. Human Neurocan is predicted to be cleaved following Met635, resulting in N-terminal (Neurocan-130) and
C-terminal (Neurocan-C) fragments whose core glycoproteins are 130 kDa and 150 kDa, respectively (4, 5). The full length molecule is expressed in the developing and juvenile brain, while its cleavage products are found throughout adulthood (3, 4). Neurocan and Neurocan-C are produced by astrocytes and accumulate in the matrix surrounding axonal bundles and neuronal cell bodies; Neurocan-130 is found mainly in the glial cell cytoplasm (6 - 8). Following brain injury, reactive astrocytes deposit increased amounts of Neurocan in the glial scar where it impedes axonal regeneration (6, 9). Neurocan inhibits neuronal adhesion and neurite outgrowth through interactions with a variety of matrix and transmembrane molecules including NCAM-L1, NCAM-1, Syndecan-3, Glypican-1, Tenascin, Contactin-2/TAG1, and HAPLN1 (1, 6, 10 - 15).

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Bioassay.

Showing Publications 1 - 3 of 3.

Publications using 6508-NC	Applications	Species
N Bielsa, M Casasamper, M Aseeri, J Casas, A Delgado, JL Abad, G Fabriàs Discovery of deoxyceramide analogs as highly selective ACER3 inhibitors in live cells European Journal of Medicinal Chemistry, 2021-02-24;216(0):113296. 2021-02-24 [PMID: 33677352] (Bioassay, Human)	Bioassay	Human
CS Sullivan, I Gotthard, EV Wyatt, S Bongu, V Mohan, RJ Weinberg, PF Maness Perineuronal Net Protein Neurocan Inhibits NCAM/EphA3 Repellent Signaling in GABAergic Interneurons Sci Rep, 2018-04-18;8(1):6143. 2018-04-18 [PMID: 29670169] (Bioassay, Human)	Bioassay	Human
Z Su, S Kishida, S Tsubota, K Sakamoto, D Cao, S Kiyonari, M Ohira, T Kamijo, A Narita, Y Xu, Y Takahashi, K Kadomatsu Neurocan, an extracellular chondroitin sulfate proteoglycan, stimulates neuroblastoma cells to promote malignant phenotypes Oncotarget, 2017-11-15;8(63):106296-106310. 2017-11-15 [PMID: 29290949] (Bioassay, Human)	Bioassay	Human

Array 6508-NC

• Neurocan Antibodies
• Neurocan Protein
• Neurocan Proteins and Enzymes