RAMP2 Antibody (773816) [Janelia Fluor® 525]

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications Flow, IHC, CyTOF-ready
Clone
773816
Clonality
Monoclonal
Host
Rat
Conjugate
Janelia Fluor 525

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RAMP2 Antibody (773816) [Janelia Fluor® 525] Summary

Immunogen
E. coli-derived recombinant mouse RAMP2
Ser45-Val159
Accession # Q9WUP0
Specificity
Detects mouse RAMP2 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human RAMP2 is observed.
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Gene
RAMP2
Innovator's Reward
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry
  • Immunohistochemistry
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for RAMP2 Antibody (773816) [Janelia Fluor® 525]

  • calcitonin receptor-like receptor activity modifying protein 2
  • Calcitonin-receptor-like receptor activity-modifying protein 2
  • CRLR activity-modifying protein 2
  • RAMP2
  • receptor (calcitonin) activity modifying protein 2
  • receptor (G protein-coupled) activity modifying protein 2
  • receptor activity modifying protein 2
  • receptor activity-modifying protein 2
  • receptor-activity-modifying protein 2

Background

The protein encoded by the RAMP2 gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol RAMP2