Detects endogenous proteins containing phosphorylated tyrosine residues. ELISA and 2D Western blot analyses using pervanadate-treated cell lysates indicate that it binds Phospho-Tyrosine in a broad manner largely independent of the surrounding amino acid sequence. Does not cross-react with proteins or peptides containing phosphorylated serine or threonine residues.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Buffer
Supplied as a 0.2 μm filtered solution in phosphate-buffered saline (PBS) with stabilizers
and preservatives.
Preservative
No Preservative
Reconstitution Instructions
Sterile PBS to a final concentration of 0.5 mg/mL.
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for Phospho-Tyrosine Antibody (179003) [HRP]
2 amino 3(4 hydroxyphenyl) propanoic acid
4 hydroxyphenylalanine
PhosphoTyrosine
pTyrosine
pY20
Tyrosine
Background
Phosphorylation of tyrosine residues in signaling proteins by protein tyrosine kinases mediates a variety of cellular processes, including cell growth, differentiation, adhesion, motility, death, and metabolism. Dysregulation of tyrosine phosphorylation has been implicated in the development of many human diseases, such as diabetes and cancer. Antibodies specific for phospho-tyrosine have been invaluable reagents in the studies of signaling pathways initiated by tyrosine phosphorylation.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
Publications for Phospho-Tyrosine Antibody (HAM1676)(10)
We have publications tested in 2 confirmed species: Human, Mouse.
We have publications tested in 3 applications: ELISA, ELISA Development (Detection), Western Blot.
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