MKP-1/DUSP1 Antibody (JJ0930)

The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Rat.

We have publications tested in 3 applications: IF/IHC, IP, WB.

Showing Publications 1 - 4 of 4.

Publications using NBP2-67909	Applications	Species
Pan J, Lin M, Xu Z Et al. CDKN2B antisense RNA 1 suppresses tumor growth in human colorectal cancer by targeting MAPK inactivator dual specificity phosphatase 1 Carcinogenesis 2021-08-26 [PMID: 34436551]
Jefsen OH, Elfving B, Wegener G, MUller HK Transcriptional regulation in the rat prefrontal cortex and hippocampus after a single administration of psilocybin J Psychopharmacol 2020-11-04 [PMID: 33143539] (WB, Rat)	WB	Rat
Lei S, Xu H, Chen N et al. MKP 1 overexpression is associated with chemoresistance in bladder cancer via the MAPK pathway Oncol Lett 2020-06-16 [PMID: 32724417] (IF/IHC, Human)	IF/IHC	Human
Li Y, Xu S, Xu Q, Chen Y Clostridium difficile toxin B induces colonic inflammation through the TRIM46/DUSP1/MAPKs and NF-kappa B signalling pathway Artif Cells Nanomed Biotechnol 2020-12-01 [PMID: 31918570] (IP, Human)	IP	Human

Array NBP2-67909

• MKP-1/DUSP1 Antibodies
• MKP-1/DUSP1 ELISA Kits
• MKP-1/DUSP1 Proteins