Map17 Antibody

MAP17 (17 kD membrane-associated protein) is a small non-glycosylated protein which localize to plasma membrane as well as Golgi apparatus, and interacts with several PDZ domain-containing proteins such as NHeRF proteins, NaPi-IIa, and NHe3. Overexpression of MAP17 in OK cells (opossum kidney epithelial cells) participates in NaPi-IIa internalization to the trans-Golgi network. In mouse, MAP17 overexpression in liver resulted in PDZK1 (NHeRF3) hepatic deficiency, suggesting MAP17's role in endogenous regulation of PDZK1 turnover. MAP17 acts as an atypical anchoring site for PDZK1 and interacts with NaPi-IIa/PDZK1 protein complex in renal proximal tubular cells, wherein its physiological role is not well known, but it does stimulate specific Na-dependent transport of mannose and glucose in Xenopus oocytes as well as in human cancer cells. MAP17 is overexpressed in a variety of human carcinomas and its overexpression strongly correlates with ROS overproduction as well as tumoral progression characterized by decreased apoptotic sensitivity with enhanced proliferation and migration in prostate, breast, ovarian cancer etc. This increase in ROS as well as tumor aggressiveness relies largely on its PDZ-binding domain as disruption of this sequence by point mutations has been shown to abolish MAP17's ability to enhance ROS production and tumorigenesis.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: WB.

Showing Publications 1 - 3 of 3.

Publications using NB400-151	Applications	Species
Pan T, Zhao Z, Lu J et al. Fenofibrate inhibits MOXD1 and PDZK1IP1 expression and improves lipid deposition and inflammation in mice with alcoholic fatty liver Life sciences 2023-12-01 [PMID: 38042280]
Vergara A, Llorens-CebriA C, Martos N et al. The membrane-associated protein 17 (MAP17) is up-regulated in response to empagliflozin on top of RAS blockade in experimental diabetic nephropathy Clinical science (London, England : 1979) 2023-01-13 [PMID: 36524468]
Silver, DL et al. Identification of small PDZK1-associated protein, DD96/MAP17, as a regulator of PDZK1 and plasma high density lipoprotein levels. J Biol Chem;278(31):28528-32. 2003-08-01 [PMID: 12754212] (WB, Mouse)	WB	Mouse

Array NB400-151

• Map17 Antibodies
• Map17 Lysate
• Map17 Proteins