IFN-kappa Antibody (1B7)

This product is produced by and distributed for Abnova, a company based in Taiwan.

IFN-kappa (Interferon kappa) is a secreted, nonglycosylated polypeptide that belongs to the IFN-kappa subclass of the type I interferon family of cytokines. It is expressed by macrophages in mice, and monocytes, dendritic cells and keratinocytes in human. IFN-kappa induces TNF-alpha, IL-10 and MCP-1 production by monocytes. Mouse IFN-kappa precursor is 199 amino acids (aa) in length. It contains a 21 aa signal sequence, plus a 178 aa mature region. There are two intrachain disulfide bonds plus a fifth unpaired cysteine. Mature mouse IFN-kappa (aa 22-199) shares 68% and 30% aa identity with rat and human IFN-kappa, respectively.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Immunohistochemistry-Paraffin, WB.

Showing Publications 1 - 10 of 10.

Publications using H00056832-M01	Applications	Species
Liu S, Dharanipragada P, Lomeli SH et al. Multi-organ landscape of therapy-resistant melanoma Nature medicine 2023-04-27 [PMID: 37106167] (Immunohistochemistry-Paraffin, Human)	Immunohistochemistry-Paraffin	Human
Mrinal S, Ranjitha U, Chang Z et al. Keratinocytes sense and eliminate CRISPR DNA through STING/IFN-? activation and APOBEC3G induction. J Clin Invest. 2023-03-16 [PMID: 36928117]
SJ Wolf, CO Audu, A Joshi, AD denDekker, WJ Melvin, FM Davis, X Xing, R Wasikowski, L Tsoi, S Kunkel, JE Gudjonsson, MX O'Riordan, JM Kahlenberg, KA Gallagher Interferon kappa (IFNk) is critical for normal wound repair and is decreased in diabetic wounds JCI Insight, 2022-05-09;0(0):. 2022-05-09 [PMID: 35358091]
Mehrnaz G, Shannon E, Lam T et al. Interferon Kappa Is a Rheostat for Development of Psoriasiform Inflammation. J Invest Dermatol. 2021-08-05 [PMID: 34364883]
Scott M, Woodby B, Ulicny J et al. Human papillomavirus type 16 E5 inhibits interferon signaling and supports episomal viral maintenance. J Virol. 2020-01-06 [PMID: 31666385]
Carbone ML, Lulli D, Passarelli F et al. Topical Plant Polyphenols Prevent Type I Interferon Signaling in the Skin and Suppress Contact Hypersensitivity. Int J Mol Sci 2018-09-06 [PMID: 30200670]
Sarkar MK, Hile GA, Tsoi LC et al. Photosensitivity and type I IFN responses in cutaneous lupus are driven by epidermal-derived interferon kappa. Ann Rheum Dis 2018-07-18 [PMID: 30021804]
Habiger C, Jager G, Walter M et al. Interferon Kappa Inhibits Human Papillomavirus 31 Transcription by Inducing Sp100 Proteins. J Virol 2015-10-21 [PMID: 26491169] (WB)	WB
Reiser J, Hurst J, Voges M et al. High risk HPV repress constitutive interferon-kappa transcription via E6 to prevent pathogen recognition receptor and antiviral gene expression. J Virol. 2011-08-17 [PMID: 21849431]
Rincon-Orozco B, Halec G, Rosenberger S, et al. Epigenetic silencing of interferon-kappa in human papillomavirus type 16-positive cells Cancer Res 2009-11-01 [PMID: 19887612]

Array H00056832-M01

• IFN-kappa Antibodies
• IFN-kappa Proteins and Enzymes