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IFN-alpha Antibody (RMMA-1) [Unconjugated]

 (6 Publications)
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Product Details

Summary
Reactivity MuSpecies Glossary
Applications ELISA, B/N
Clone
RMMA-1
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Fluorescein
22100-3
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IFN-alpha Antibody (RMMA-1) [Unconjugated] Summary

Immunogen
Mouse Interferon alpha
Specificity
Neutralizes mouse interferon alpha; binds to mouse interferon alpha
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Rat
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Endotoxin Note
<1.0 EU per 1 μg of the antibody by the LAL method.
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Applications/Dilutions

Dilutions
  • ELISA
  • Neutralization
Publications
Read Publications using
22100-1 in the following applications:

Packaging, Storage & Formulations

Storage
After receipt, the product may be stored at -20°C for short-term use (≤ 6 months). For long-term storage, we recommend storing the product at -70°C or below for retention of full activity. When thawing, the contents of the tube should be apportioned in separate tubes so that freezing and thawing is kept to a minimum. Re-freezing should be done on dry ice or in a dry ice/alcohol bath. Further dilution of the product should be in buffers containing protein such as 0.1% bovine serum albumin (BSA).
Buffer
50mM Sodium Bicarbonate; 0.2M Sodium Chloride, pH 8.0
Preservative
No Preservative

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IFN-alpha Antibody (RMMA-1) [Unconjugated]

  • IFNA
  • IFNA2
  • IFNA2b
  • IFNalpha
  • IFN-alpha
  • IFN-alphaA
  • INFA2
  • interferon alpha 2
  • LeIF D

Background

Interferon-alpha (IFN-alpha), also known as leukocyte interferon, represents a group of related but distinct proteins that share over 95% amino acid sequence homology. They are members of the type I interferon family which share a common cell surface receptor composed of two subunits, a 100 kDa ligand-binding subunit (IFN-alpha R2) and a 125 kDa ligand binding and signal transduction subunit (IFN-alpha R1) that is involved both in ligand binding and signal transduction. IFN-alpha has both anti-viral and immunomodulatory activities on target cells.
  1. Asselin-Paturel, C. et al. 2005, J. Exp. Med. 201:1157.
  2. Mellor, A.L. et al. 2005, J. Immunol. 175:5601.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for IFN-alpha Antibody (22100-1)(6)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: ELISA Development, Neutralization.


Filter By Application
ELISA Development
(2)
Neutralization
(3)
All Applications
Filter By Species
Mouse
(5)
All Species
Showing Publications 1 - 6 of 6.
Publications using 22100-1 Applications Species
K Man, L Pang, OWH Yeung, KTP Ng, H Liu, J Zhu, J Liu, X Yang, T Ding, W Qiu, Y Wang, TLS Chiu, Z Chen, CM Lo Postoperative plasmacytoid dendritic cells secrete IFN-alpha to promote recruitment of myeloid-derived suppressor cells and drive hepatocellular carcinoma recurrence Cancer Research, 2022-11-15;0(0):. 2022-11-15 [PMID: 36112065] (Neutralization, Mouse) Neutralization Mouse
Sayan Ghosh, Archana Padmanabhan, Tanuja Vaidya, Alan M. Watson, Imran A. Bhutto, Stacey Hose et al. Neutrophils homing into the retina trigger pathology in early age-related macular degeneration Communications Biology 9/20/2019 [PMID: 31552301]
Rycroft D, Sosabowski J, Coulstock E, Davies M, Morrey J, Friel S, Kelly F, Hamatake R, Ovecka M, Prince R, Goodall L, Sepp A, Walker A Pharmacokinetic characteristics, pharmacodynamic effect and in vivo antiviral efficacy of liver-targeted interferon alpha. PLoS ONE, 2015-02-17;10(2):e0117847. 2015-02-17 [PMID: 25689509] (ELISA Development, Mouse) ELISA Development Mouse
von Buttlar H, Siegemund S, Buttner M, Alber G Identification of Toll-like receptor 9 as parapoxvirus ovis-sensing receptor in plasmacytoid dendritic cells. PLoS ONE, 2014-08-29;9(8):e106188. 2014-08-29 [PMID: 25171368] (ELISA Development, Mouse) ELISA Development Mouse
Baldwin H, Pallas K, King V, Jamieson T, McKimmie C, Nibbs R, Carballido J, Jaritz M, Rot A, Graham G Microarray analyses demonstrate the involvement of type I interferons in psoriasiform pathology development in D6-deficient mice. J Biol Chem, 2013-11-05;288(51):36473-83. 2013-11-05 [PMID: 24194523] (Neutralization, Mouse) Neutralization Mouse
Qin L, Greenland JR, Moriya C Effects of type I interferons on the adjuvant properties of plasmid granulocyte-macrophage colony-stimulating factor in vivo. J. Virol., 2007-07-25;81(19):10606-13. 2007-07-25 [PMID: 17652387] (Neutralization, Mouse) Neutralization Mouse

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