Human/Mouse/Rat Total HSP70/HSPA1A DuoSet IC ELISA, 2 Plate

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The heat shock proteins are a highly conserved family of stress response proteins. HSPs function primarily as molecular chaperones, facilitating the folding of other cellular proteins, preventing protein aggregation, or targeting improperly folded proteins to specific degradative pathways. Some HSPs are expressed at low levels under normal physiological conditions but show dramatically increased expression in response to cellular stress, others are constitutively expressed. Specific HSPs play a role in regulating apoptosis by interacting directly with key components of the apoptotic pathway.

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Ovine.

Showing Publications 1 - 10 of 25. Show All 25 Publications. Collapse Publications.

Publications using DYC1663-2	Applications	Species
Lennartz, P;Thölke, D;Bashiri Dezfouli, A;Pilz, M;Lobinger, D;Messner, V;Zanth, H;Ainslie, K;Kafshgari, MH;Rammes, G;Ballmann, M;Schlegel, M;Foulds, GA;Pockley, AG;Schmidt-Graf, F;Multhoff, G; Biomarkers in Adult-Type Diffuse Gliomas: Elevated Levels of Circulating Vesicular Heat Shock Protein 70 Serve as a Biomarker in Grade 4 Glioblastoma and Increase NK Cell Frequencies in Grade 3 Glioma Biomedicines 2023-12-07 [PMID: 38137456] (Human)		Human
OM David, KL Lategan, MF de Cortale, EJ Pool The Stability and Anti-Angiogenic Properties of Titanium Dioxide Nanoparticles (TiO2NPs) Using Caco-2 Cells Biomolecules, 2022-09-21;12(10):. 2022-09-21 [PMID: 36291543] (Human)		Human
P Innamarato, J Morse, A Mackay, S Asby, M Beatty, J Blauvelt, S Kidd, JE Mullinax, AA Sarnaik, S Pilon-Thom Intralesional injection of rose bengal augments the efficacy of gemcitabine chemotherapy against pancreatic tumors BMC Cancer, 2021-06-30;21(1):756. 2021-06-30 [PMID: 34187428] (Mouse)		Mouse
RJ Playford, N Choudhry, P Kelly, T Marchbank Effects of Bovine Colostrum with or without Egg on In Vitro Bacterial-Induced Intestinal Damage with Relevance for SIBO and Infectious Diarrhea Nutrients, 2021-03-22;13(3):. 2021-03-22 [PMID: 33809940] (Human)		Human
T Ratschker, L Egenberger, M Alev, L Zschiesche, J Band, E Schreiber, B Frey, A Derer, C Alexiou, C Janko Mitoxantrone-Loaded Nanoparticles for Magnetically Controlled Tumor Therapy-Induction of Tumor Cell Death, Release of Danger Signals and Activation of Immune Cells Pharmaceutics, 2020-09-27;12(10):. 2020-09-27 [PMID: 32992645] (Human)		Human
M Hader, DP Savcigil, A Rosin, P Ponfick, S Gekle, M Wadepohl, S Bekeschus, R Fietkau, B Frey, E Schlücker, US Gaipl Differences of the Immune Phenotype of Breast Cancer Cells after Ex Vivo Hyperthermia by Warm-Water or Microwave Radiation in a Closed-Loop System Alone or in Combination with Radiotherapy Cancers (Basel), 2020-04-27;12(5):. 2020-04-27 [PMID: 32349284] (Human)		Human
B Theivanthi, KS Evans, NC DeVito, MP Plebanek, M Sturdivant, LP Wachsmuth, AK Salama, Y Kang, D Hsu, JM Balko, DB Johnson, M Starr, AB Nixon, A Holtzhause, BA Hanks A tumor-intrinsic PD-L1-NLRP3 inflammasome signaling pathway drives resistance to anti-PD-1 immunotherapy J. Clin. Invest., 2020-05-01;0(0):. 2020-05-01 [PMID: 32017708] (Mouse)		Mouse
A Kühnel, D Schilling, SE Combs, B Haller, M Schwab, G Multhoff Radiosensitization of HSF-1 Knockdown Lung Cancer Cells by Low Concentrations of Hsp90 Inhibitor NVP-AUY922 Cells, 2019-09-28;8(10):. 2019-09-28 [PMID: 31569342] (Human)		Human
T Haider, E Simader, O Glück, HJ Ankersmit, T Heinz, S Hajdu, LL Negrin Systemic release of heat-shock protein 27 and 70 following severe trauma Sci Rep, 2019-07-03;9(1):9595. 2019-07-03 [PMID: 31270381] (Human)		Human
NS Nunes, P Chandran, M Sundby, F Visioli, F da Costa G, SR Burks, AH Paz, JA Frank Therapeutic ultrasound attenuates DSS-induced colitis through the cholinergic anti-inflammatory pathway EBioMedicine, 2019-06-26;0(0):. 2019-06-26 [PMID: 31253515] (Mouse)		Mouse
J Nam, S Son, LJ Ochyl, R Kuai, A Schwendema, JJ Moon Chemo-photothermal therapy combination elicits anti-tumor immunity against advanced metastatic cancer Nat Commun, 2018-03-14;9(1):1074. 2018-03-14 [PMID: 29540781] (Mouse)		Mouse
A Dyer, Y Di, H Calderon, S Illingwort, G Kueberuwa, A Tedcastle, P Jakeman, SL Chia, A Brown, MA Silva, D Barlow, J Beadle, T Hermiston, DJ Ferguson, B Champion, KD Fisher, LW Seymour Oncolytic Group B Adenovirus Enadenotucirev Mediates Non-apoptotic Cell Death with Membrane Disruption and Release of Inflammatory Mediators Mol Ther Oncolytics, 2016-12-10;4(0):18-30. 2016-12-10 [PMID: 28345021] (Human)		Human
Disrupting the blood-brain barrier by focused ultrasound induces sterile inflammation Proc. Natl. Acad. Sci. U.S.A, 2016-12-19;0(0):. 2016-12-19 [PMID: 27994152] (Rat)		Rat
A M Sapozhniko Study of Immunomodulatory Effects of Extracellular HSP70 in a Mouse Model of Allergic Airway Inflammation Biochemistry Mosc., 2016-11-01;81(11):1384-1395. 2016-11-01 [PMID: 27914463] (Mouse)		Mouse
L Kinzel, A Ernst, M Orth, V Albrecht, R Hennel, N Brix, B Frey, US Gaipl, G Zuchtriege, CA Reichel, A Blutke, D Schilling, G Multhoff, M Li, M Niyazi, AA Friedl, N Winssinger, C Belka, K Lauber A novel HSP90 inhibitor with reduced hepatotoxicity synergizes with radiotherapy to induce apoptosis, abrogate clonogenic survival, and improve tumor control in models of colorectal cancer Oncotarget, 2016-07-12;7(28):43199-43219. 2016-07-12 [PMID: 27259245] (Human)		Human
Lee C, Kokolus K, Leigh N, Capitano M, Hylander B, Repasky E Defining immunological impact and therapeutic benefit of mild heating in a murine model of arthritis. PLoS ONE, 2015-03-20;10(3):e0120327. 2015-03-20 [PMID: 25793532] (Mouse)		Mouse
Tulapurkar M, Ramarathnam A, Hasday J, Singh I Bacterial lipopolysaccharide augments febrile-range hyperthermia-induced heat shock protein 70 expression and extracellular release in human THP1 cells. PLoS ONE, 2015-02-06;10(2):e0118010. 2015-02-06 [PMID: 25659128] (Human)		Human
Hillman N, Kemp M, Miura Y, Kallapur S, Jobe A Sustained inflation at birth did not alter lung injury from mechanical ventilation in surfactant-treated fetal lambs. PLoS ONE, 2014-11-24;9(11):e113473. 2014-11-24 [PMID: 25419969] (Ovine)		Ovine
Roy A, Ganesh G, Sippola H, Bolin S, Sawesi O, Dagalv A, Schlenner S, Feyerabend T, Rodewald H, Kjellen L, Hellman L, Abrink M Mast cell chymase degrades the alarmins heat shock protein 70, biglycan, HMGB1, and interleukin-33 (IL-33) and limits danger-induced inflammation. J Biol Chem, 2013-11-20;289(1):237-50. 2013-11-20 [PMID: 24257755] (Mouse)		Mouse
Gupta A, Cooper Z, Tulapurkar M, Potla R, Maity T, Hasday J, Singh I Toll-like receptor agonists and febrile range hyperthermia synergize to induce heat shock protein 70 expression and extracellular release. J Biol Chem, 2012-12-04;288(4):2756-66. 2012-12-04 [PMID: 23212905] (Human, Mouse)		Human, Mouse
Cwiklinska H, Mycko MP, Szymanska B Aberrant stress-induced Hsp70 expression in immune cells in multiple sclerosis. J. Neurosci. Res., 2010-11-01;88(14):3102-10. 2010-11-01 [PMID: 20806409] (Human)		Human
Kocsis J, Madaras B, Toth EK, Fust G, Prohaszka Z Serum level of soluble 70-kD heat shock protein is associated with high mortality in patients with colorectal cancer without distant metastasis. Cell Stress Chaperones, 2009-07-04;15(2):143-51. 2009-07-04 [PMID: 19578980] (Human)		Human
Zhou F, Xing D, Chen WR Regulation of HSP70 on activating macrophages using PDT-induced apoptotic cells. Int. J. Cancer, 2009-09-15;125(6):1380-9. 2009-09-15 [PMID: 19533746] (Mouse)		Mouse
Figueiredo C, Wittmann M, Wang D, Dressel R, Seltsam A, Blasczyk R, Eiz-Vesper B Heat shock protein 70 (HSP70) induces cytotoxicity of T-helper cells. Blood, 2008-11-18;113(13):3008-16. 2008-11-18 [PMID: 19018093] (Human)		Human
Li CJ, Ning W, Matthay MA, Feghali-Bostwick CA, Choi AM MAPK pathway mediates EGR-1-HSP70-dependent cigarette smoke-induced chemokine production. Am. J. Physiol. Lung Cell Mol. Physiol., 2007-05-01;292(5):L1297-303. 2007-05-01 [PMID: 17494953] (Human)		Human
Show All 25 Publications. Collapse Publications.

Array DYC1663-2

• HSP70/HSPA1A Antibodies
• HSP70/HSPA1A Lysate
• HSP70/HSPA1A Proteins
• HSP70/HSPA1A ELISAs
• HSP70/HSPA1A Proteins and Enzyme