![Immunohistochemistry-Paraffin: Growth Hormone Antibody (SPM106) [NBP2-54352] - Formalin-fixed, paraffin-embedded Human Pituitary stained with Growth Hormone Monoclonal Antibody (SPM106).](http://images.novusbio.com/fullsize/Growth-Hormone-Antibody-SPM106-Immunohistochemistry-Paraffin-NBP2-54352-img0001.jpg "Immunohistochemistry-Paraffin: Growth Hormone Antibody (SPM106) [NBP2-54352] - Formalin-fixed, paraffin-embedded Human Pituitary stained with Growth Hormone Monoclonal Antibody (SPM106).")
| Reactivity | HuSpecies Glossary |
| Applications | Flow, ICC/IF, IHC, CyTOF-ready |
| Clone | SPM106 |
| Clonality | Monoclonal |
| Host | Mouse |
| Conjugate | Unconjugated |
| Format | Azide and BSA Free |
| Concentration | 1 mg/ml |
| Description | 1.0 mg/ml of antibody purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS WITHOUT BSA & azide. Also available at 200 ug/ml WITH BSA & azide (NBP2-53263). Antibody with azide - store at 2 to 8C. Antibody without azide - store at -20 to -80C. |
| Immunogen | A recombinant fragment (around aa58-187) of human Growth Hormone (GH) protein (exact sequence is proprietary) (Uniprot: P01241) |
| Localization | Cytoplasmic |
| Marker | Pituitary Marker |
| Specificity | Pituitary growth hormone (GH) plays a crucial role in stimulating and controlling the growth, metabolism and differentiation of many mammalian cell types by modulating the synthesis of multiple mRNA species. These effects are mediated by the binding of GH to its membrane-bound receptor, GHR, and involve a phosphorylation cascade that results in the modulation of numerous signaling pathways. GH is synthesized by acidophilic or somatotropic cells of the anterior pituitary gland. Anti-GH is a useful marker in classification of pituitary tumors and the study of pituitary disease (acromegaly). |
| Isotype | IgG2b Kappa |
| Clonality | Monoclonal |
| Host | Mouse |
| Gene | GH1 |
| Purity | Protein A or G purified |
| Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
| Dilutions |
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| Application Notes | Immunohistochemistry (Formalin-fixed): 1-2ug/ml for 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes. Optimal dilution for a specific application should be determined. |
| Theoretical MW | 20 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
| Storage | Store at -20 to -80C. Avoid freeze-thaw cycles. |
| Buffer | 10 mM PBS |
| Preservative | No Preservative |
| Concentration | 1 mg/ml |
| Purity | Protein A or G purified |
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Secondary Antibodies |
Isotype Controls |
Research Areas for Growth Hormone Antibody (NBP2-54352)Find related products by research area.
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Growth hormone (GH, somatotropin, hGH, pituitary growth hormone) GH is a member of the large family of growth factors that includes prolactin, placental lactogens, proliferins, and somatolactin. Additionally, GH is a 191-amino acid, single-chain polypeptide that is synthesized, stored, and secreted by somatotropic ... Read full blog post. |
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Somatostatin Receptor 2: Treating Patients Who Cannot Stop Growing Acromegaly is a rare life-shortening disease caused by elevated levels of growth hormone (GH) secreted by a tumor on the pituitary gland. Treatments include somatostatin analogs, which activate somatostatin receptor 2 (SSTR2), reducing GH secretion an... Read full blog post. |
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| Gene Symbol | GH1 |
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