Glutathione S-Transferase mu 1/GSTM1 Antibody

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.

Showing Publications 1 - 3 of 3.

Publications using NB300-932	Applications	Species
Pasello M, Manara MC, Michelacci F et al. Targeting glutathione-S transferase enzymes in musculoskeletal sarcomas: a promising therapeutic strategy Anal Cell Pathol (Amst) 2011-01-01 [PMID: 21673434] (WB, Human)	WB	Human
Pasello M, Michelacci F, Scionti I et al. Overcoming Glutathione S-Transferase P1-Related Cisplatin Resistance in Osteosarcoma. Cancer Res;68(16):6661-6668. 2008-01-01 [PMID: 18701490]
Lee KA, Kim SH, Woo HY et al. Increased frequencies of glutathione S-transferase (GSTM1 and GSTT1) gene deletions in Korean patients with acquired aplastic anemia. Blood 2001-12-01 [PMID: 11719393]

Array NB300-932

• Glutathione S-Transferase mu 1/GSTM1 Antibodies
• Glutathione S-Transferase mu 1/GSTM1 ELISA Kits
• Glutathione S-Transferase mu 1/GSTM1 Lysate
• Glutathione S-Transferase mu 1/GSTM1 Proteins
• Glutathione S-Transferase mu 1/GSTM1 Proteins and Enzyme