Recombinant Human DNA Polymerase beta His Protein

DNA polymerase beta, also known as POLB, belongs to the DNA polymerase type-X family. In eukaryotic cells, DNA polymerase beta (POLB) performs base excision repair (BER) required for DNA maintenance, replication, recombination, and drug resistance. POLB has two distinct domains, the larger is the polymerase domain itself, whereas a small basic N-terminal domain contains an AP lyase activity that excises the abasic sugar-phosphate residue at the strand break. POLB fills single nucleotide gaps in DNA produced by the base excision repair pathway of mammalian cells. Overexpression of POLB, as found in some human tumors, could confer an increase in spontaneous mutagenesis. Recombinant human POLB protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: EnzAct.

Showing Publications 1 - 2 of 2.

Publications using NBP1-72434	Applications	Species
Baljinnyam T, Conrad JW, Sowers ML et al. Characterization of a Novel Thermostable DNA Lyase Used To Prepare DNA for Next-Generation Sequencing Chemical research in toxicology 2023-01-16 [PMID: 36647573] (EnzAct, Human)	EnzAct	Human
Hsu CW, Conrad JW, Sowers ML et al. A combinatorial system to examine the enzymatic repair of multiply damaged DNA substrates Nucleic acids research 2022-07-22 [PMID: 35776119] (EnzAct, Human)	EnzAct	Human

Array NBP1-72434

• DNA Polymerase beta Antibodies
• DNA Polymerase beta Proteins