APE Antibody

Apurinic / apyrimidinic endonuclease (APE1 or REF1) is responsible for the incision of DNA basic sites during base excision repair. It has also been shown to stimulate the DNA binding activity of numerous transcription factors that are involved in cancer promotion and progression. Alterations in APE1 levels have been described in some cancers. APE1 is part of the cellular response to oxidative stress and protects cells from the genotoxic and cytotoxic effect of oxidizing agents.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: ICC/IF, WB.

Showing Publications 1 - 6 of 6.

Publications using NB100-897	Applications	Species
Mangiapane G, Parolini I, Conte K et al. Enzymatically active apurinic/apyrimidinic endodeoxyribonuclease 1 is released by mammalian cells through exosomes The Journal of biological chemistry 2021-03-19 [PMID: 33753167] (WB, Human)	WB	Human
Pascut D, Sukowati CHC, Antoniali G et al. Serum AP-endonuclease 1 (sAPE1) as novel biomarker for hepatocellular carcinoma Oncotarget 2019-01-08 [PMID: 30719231] (WB, Human)	WB	Human
Sandomenico A, Foca A, Sanguigno L et al. Monoclonal antibodies against pools of mono- and polyacetylated peptides selectively recognize acetylated lysines within the context of the original antigen. MAbs 2016-08-25 [PMID: 27560983] (ICC/IF)	ICC/IF
Bhakat KK, Sengupta S, Adeniyi VF et al. Regulation of limited N-terminal proteolysis of APE1 in tumor via acetylation and its role in cell proliferation. Oncotarget 2016-04-19 [PMID: 26981776]
Allen D, Herbert DC, McMahan CA et al. Mutagenesis is elevated in male germ cells obtained from DNA polymerase-beta heterozygous mice. Biol Reprod 2008-11-01 [PMID: 18650495]
Demple B, Herman T, Chen DS. Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes. Proc Natl Acad Sci U S A 1991-12-15 [PMID: 1722334]

Array NB100-897

• APE Antibodies
• APE Antibody Pack
• APE Lysates
• APE Proteins