AIF Antibody

AIF, or apoptosis-inducing factor, is a flavoprotein localized to the mitochondrial membrane that plays a primary role in caspase-independent cell death, or apoptosis (1,2). AIF translocates to the nucleus when apoptosis is induced and causes mitochondria to release the apoptogenic proteins, cytochrome c and caspase-9. Apoptotic activity of AIF leads to chromatin condensation and DNA fragmentation (1). Similar to cytochrome c, AIF is a bifunctional protein with an oxidoreductase function and a second apoptogenic function. In contrast to cytochrome c, however, AIF acts in a caspase-independent fashion (2,3,4).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.

Showing Publications 1 - 2 of 2.

Publications using NBP2-42496	Applications	Species
Pandolfo M, Rai M, Remiche G et al. Cerebellar ataxia, neuropathy, hearing loss, and intellectual disability due to AIFM1 mutation Neurol Genet 2020-06-01 [PMID: 32337346] (WB, Human)	WB	Human
Lewis EM, Wilkinson AS, Jackson JS et al. The enzymatic activity of apoptosis-inducing factor supports energy metabolism benefiting the growth and invasiveness of advanced prostate cancer cells. J Biol Chem 2012-12-01 [PMID: 23118229]

Array NBP2-42496

• AIF Antibodies
• AIF ELISA Kit
• AIF Lysates
• AIF Proteins