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5-HT7 Antibody (1015322) [Unconjugated]

Images

 
HEK293 human embryonic kidney cell line transfected with human 5-HT7 and eGFP was stained with (A) Mouse Anti-Human 5-HT7 Monoclonal Antibody (Catalog # MAB10325) or (B) isotype control antibody (Catalog # MAB0041) ...read more
5-HT7 was detected in immersion fixed paraffin-embedded sections of human brain (hypothalamus) using Mouse Anti-Human 5-HT7 Monoclonal Antibody (Catalog # MAB10325) at 5 µg/mL for 1 hour at room temperature ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, IHC, CyTOF-ready
Clone
1015322
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

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5-HT7 Antibody (1015322) [Unconjugated] Summary

Immunogen
 Synthetic peptide containing human 5-HTR7
Accession # P34969
Specificity
Detects human 5-HTR7 in direct ELISAs.
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Purity Statement
Protein A or G purified from cell culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry 0.25 ug/10^6 cells
  • Immunohistochemistry 5-25 ug/mL

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for 5-HT7 Antibody (1015322) [Unconjugated]

  • 5HT7
  • 5-HT7
  • 5-HT-7
  • 5-HT75-hydroxytryptamine receptor 7
  • 5-HT-X
  • 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)
  • HTR7
  • serotonin 5-HT-7 receptor
  • Serotonin receptor 7

Background

HTR2B is a G-protein coupled receptor for serotonin. The 5HT2 receptors mediate many of the central and peripheral physiologic functions of serotonin. 5HT2B plays a role in the regulation of dopamine and serotonin release, serotonin uptake and in the regulation of extracellular dopamine and serotonin levels.  It also plays a role in pulmonary vasoconstriction and regulating cardiac structure and functions.  5HT2B receptors were shown to be expressed in human failing heart and have been strongly implicated in drug induced valvular heart disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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