5-HT7 Antibody (1015322) [Unconjugated] Summary
Immunogen |
Synthetic peptide containing human 5-HTR7 Accession # P34969 |
Specificity |
Detects human 5-HTR7 in direct ELISAs.
|
Source |
N/A |
Isotype |
IgG2b |
Clonality |
Monoclonal |
Host |
Mouse |
Purity Statement |
Protein A or G purified from cell culture supernatant |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- CyTOF-ready
- Flow Cytometry 0.25 ug/10^6 cells
- Immunohistochemistry 5-25 ug/mL
|
Packaging, Storage & Formulations
Storage |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. - 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
|
Buffer |
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS. |
Reconstitution Instructions |
Reconstitute at 0.5 mg/mL in sterile PBS. |
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for 5-HT7 Antibody (1015322) [Unconjugated]
Background
HTR2B is a G-protein coupled receptor for serotonin. The 5HT2
receptors mediate many of the central and peripheral physiologic functions of
serotonin. 5HT2B plays a role in the regulation of dopamine and serotonin
release, serotonin uptake and in the regulation of extracellular dopamine and
serotonin levels. It also plays a role
in pulmonary vasoconstriction and regulating cardiac structure and functions. 5HT2B receptors were shown to be expressed in
human failing heart and have been strongly implicated in drug induced valvular
heart disease.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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