5-HT4 Antibody (631769) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

5-HT4 (5-hydroxytryptamine receptor 4), also known as HTR4 or 5HT4R, is an approximately 45 kDa multipass serotonin receptor that is expressed in the brain, gastrointestinal tract, bladder, vascular endothelial cells, atrium, kidney, and adrenal gland. It is involved in the regulation of learning, memory, anxiety, smooth muscle contraction, and adrenal corticosteroid secretion. Alternate splicing of human 5-HT4 generates multiple isoforms with either a 14 aa insertion in the second extracellular loop or a deletion or various substitutions in the C-terminal cytoplasmic region. Different isoforms show tissue specific expression patterns or increased activity in the absence of ligand. Human 5-HT4 shares 94% and 88% aa sequence identity with mouse and rat 5-HT4, respectively.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publication using MAB6545	Applications	Species
Anna G. Orr, Edward C. Hsiao, Max M. Wang, Kaitlyn Ho, Daniel H. Kim, Xin Wang et al. Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory Nature Neuroscience 2015-03-01 [PMID: 25622143]

Array MAB6545

• 5-HT4 Antibodies
• 5-HT4 ELISA Kits
• 5-HT4 Lysates
• 5-HT4 Proteins