PRAS40 Products

Description

Proline Rich Akt Substrate (PRAS40) is a 40 kDa substrate of Akt. Akt and PRAS40 can be found in the phosphoinositide 3 kinase (PI3K) pathway, which plays a role in glucose uptake, cell growth, and apoptosis inhibition. PRAS40 is a 14-3-3 binding protein that reacts with insulin, but whose precise function is not yet known. It may bind SH3 and WW domain containing proteins resulting in a change of function. Activated Akt phosphorylates PRAS40 on threonine 246. Mutation of PRAS40 threonine 246 has been shown to be apoptotic.

Bioinformatics

Entrez	84335 Human
Uniprot	NP_001092102 Human NP_115751 Human Q96B36 Human
Product By Gene ID	84335
Alternate Names	40 kDa AKT1 substrate 1 (proline-rich) MGC2865 proline-rich AKT1 substrate 1,40 kDa proline-rich AKT substrate

Research Areas for PRAS40

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Autophagy
Cancer
Growth and Development
Lipid and Metabolism
mTOR Pathway
Neuronal Cell Markers
Neuroscience
Phospho-Specific
Tumor Suppressors

Related PRAS40 Blog Posts

Check out the latest blog posts on PRAS40.

Mapping Signal Transduction with mTOR Antibodies The protein encoded by mTOR (mammalian target of rapamycin), also known as dTOR in Drosophila, belongs to a family of phosphatidylinositol kinase-related kinases. These kinases regulate fundamental processes of cell growth, proliferation, metabolism...    Read more.

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