TBK1 Products

Description

NFkappaB-activating kinase (NAK) also known as TANK binding kinase-1 (TBK1) or tumor necrosis factor receptor associated factor 2-associated kinase (T2K) is a serine/threonine protein that belongs to the IkB kinase (IKK) family (1). Similar to IKK alpha and beta (2), NAK induces IkB degradation and NF-kB activity. NAK is activated by phorbol ester tumour promoters and growth factors, whereas catalytically inactive NAK specifically inhibits activation of NF-kB by protein kinase C-epsilon (PKCepsilon). NAK specifically phosphorylates IkB alpha on Serine 36 and NFkB subunit RelA (p65) on Serine 536 (3). NAK is also known to interact with TANK, TRAF-2 and TRIF (4).

Bioinformatics

Uniprot	AAH34950 Human AAH34950.1 Human NP_037386 Human NP_037386.1 Human Q9UHD2 Human
Product By Gene ID	29110
Alternate Names	EC 2.7.11 EC 2.7.11.1 FLJ11330 NAK serine/threonine-protein kinase TBK 1 NAKserine/threonine-protein kinase TBK1 NF-kappa-B-activating kinase T2K TANK-binding kinase 1NF-kB-activating kinase TBK 1

Research Areas for TBK1

Find related products by research area and learn more about each of the different research areas below.

Phospho-Specific
Protein Kinase
Signal Transduction

Related TBK1 Blog Posts

Check out the latest blog posts on TBK1.

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Autophagy Research Update: What a difference a year makes! By Christina Towers, PhD Over the last two decades the field of autophagy has exploded! Innovative techniques, comprehensive analysis and disease-relevant models have yielded basic and clinical discoveries of conseque...    Read more.

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