NAIP Products

Description

Neuronal apoptosis inhibitor protein (NAIP) was the first human inhibitor of apoptosis protein (IAP) identified and was discovered by its association with the neurodegenerative disorder spinal muscular atrophy. Members of the IAP family contain one to three copies of an approximately 70 amino acid motif termed baculovirus IAP repeat (BIR); these BIRs promote protein-protein interactions with various caspases such as caspase-3, -7, and -9 as well as members of the TRAF family of signal molecules. Unlike other IAPs however, NAIP requires ATP to bind caspase-9 and is not inhibited by the IAP-inhibiting molecule Smac/DIABLO, suggesting that NAIP is unique among the IAPs in its regulation of its activity. Finally, although only one human NAIP protein has been identified, other shorter NAIP mRNA transcripts have been reported.

Bioinformatics

Uniprot	AAC52047 Human NP_004527 Human NP_004527.2 Human Q13075 Human
Product By Gene ID	4671
Alternate Names	baculoviral IAP repeat-containing 1 BIRC1baculoviral IAP repeat-containing protein 1 FLJ18088 FLJ42520 FLJ58811 Neuronal apoptosis inhibitory protein NLR family, apoptosis inhibitory protein NLR family, BIR domain containing 1 NLRB1 nucleotide-binding oligomerization domain, leucine rich repeat and BIR domaincontaining 1 psi neuronal apoptosis inhibitory protein psiNAIP

Research Areas for NAIP

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer

Related NAIP Blog Posts

Check out the latest blog posts on NAIP.

Survivin is thrivin' The survivin anti-apoptotic protein is the smallest member of a large family of proteins such as X-linked IAP, c-IAP1 and 2, IAP-like protein-2, melanoma IAP, Livin, and NAIP. Survivin regulates basic physiological events such as the cell cycle, tumor...    Read more.

The Ins and Outs of Survivin By Rachel M.A. Linger, Ph.D.What is survivin?Survivin is a small (16.5 kDa) protein normally found in human fetal tissue. In contrast, survivin is typically undetectable in most normal adult tissues. Expression of ...    Read more.

Survivin - an inhibitor of apoptosis protein Survivin is an anti-apoptotic protein which is the smallest protein within a large family of proteins including X-linked IAP, c-IAP1 and 2, IAP-like protein-2, melanoma IAP, NAIP, and Livin. Survivin is responsible for a wide range of basic cellula...    Read more.

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