IRS1 Products

Description

Insulin receptor substrates (IRS), the major intracellular substrates of the insulin receptor (IR), are adaptor proteins that transduce signals from the IR to downstream effectors that are important for the biological effect of insulin (1-2). After insulin stimulation, IRS proteins are rapidly phosphorylated on multiple tyrosine residues. Once phosphorylated, IRS proteins bind and activate Grb-2, SHP2 and the PI3-K p85 subunit (2-3). IRS-1 functions as one of the key regulators of IR and the insulin-like growth factor-1 receptor. Disruption of IRS-1 causes growth retardation and insulin resistance associated with hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation (4-5)

Bioinformatics

Entrez	16367 Mouse 25467 Rat 3667 Human
Uniprot	NP_005535.1 Human NP_076995 Human P35568 Human
Product By Gene ID	3667
Alternate Names	HIRS-1 insulin receptor substrate 1 IRS-1

Research Areas for IRS1

Find related products by research area and learn more about each of the different research areas below.

Autophagy
Cancer
Diabetes Research
Lipid and Metabolism
mTOR Pathway
Nutrient Sensing in the Brain
Phospho-Specific
Signal Transduction

Related IRS1 Blog Posts

Check out the latest blog posts on IRS1.

Signalling Advances in Adiponectin Antibody Research Adiponectin is an adipocytokine protein that positively regulates metabolism of lipids and glucose by suppressing glucose production from the liver, stimulating insulin sensitivity, and increasing the rate of fatty acid oxidation and glucose uptake. I...    Read more.

Insulin signaling in adipocytes: Carbohydrate-signaling transcription factor ChREBP is the link between lipolytic enzyme Hormone-Sensitive Lipase and lipogenic enzyme ELOVL6 By Jamshed Arslan, Pharm. D., PhD. Insulin resistance in adipocytes is a major feature of metabolic syndrome   . Disrupted adipose tissue metabolism can lead to accumulation of lipid intermediates in insul...    Read more.

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