HIF-3 alpha Products

Description

Hypoxia-inducible factor (HIF) is one of the most important factors in the cellular response to hypoxia, by transcriptionally activating genes encoding proteins that mediate adaptive responses to reduced oxygen availability. HIF is a heterodimer consisting of one of three subunits, HIF1 alpha, HIF2 alpha, or HIF3 alpha. HIF target genes play critical roles in metabolism, angiogenesis, cell proliferation and cell survival. HIF3 alpha protein is one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha 3 subunit lacks the transactivation domain found in factors containing either the alpha 1 or alpha 2 subunits. HIF3 alpha may be a marker for tumor growth and angiogenesis.

Bioinformatics

Entrez	53417 Mouse 64344 Human 64345 Rat
Uniprot	AAH26308 Human AAH26308.1 Human AAH80551.1 Human NP_690008 Human Q9Y2N7 Human
Product By Gene ID	64344
Alternate Names	Basic-helix-loop-helix-PAS protein MOP7 BHLHE17 bHLHe17HIF-3A2 Class E basic helix-loop-helix protein 17 HIF-3A4 HIF-3-alpha HIF3-alpha hypoxia inducible factor 3, alpha subunit hypoxia-inducible factor 3-alpha hypoxia-inducible factor-3 alpha 4 Inhibitory PAS domain protein IPASHIF3-alpha-1 Member of PAS protein 7 MOP7PAS domain-containing protein 7 PASD7HIF-3A

Research Areas for HIF-3 alpha

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cancer
Chromatin Research
HIF Target Genes
Hypoxia
Transcription Factors and Regulators

Related HIF-3 alpha Blog Posts

Check out the latest blog posts on HIF-3 alpha.

HIF-2 alpha: HIF1A's Homologue with Similar and Divergent Functions HIF-2 alpha is a member of the heterodimeric hypoxia-inducible factors/HIFs family (HIF-1, HIF-2, and HIF-3) which contains a common beta subunit but differ in their alpha subunits. Also called as EPAS1 or Mop2, HIF-2 alpha regulates cellular adapt...    Read more.

A Role for HIF-1 alpha Antibody in Renal Research The Hypoxia Inducible Factors (HIFs) are a family of mammalian transcription factors which are expressed in response to low cellular oxygen concentrations (hypoxia). Three human hypoxia inducible factors have been identified, HIF-1, HIF-2 and HIF-3, e...    Read more.

HIF Antibodies: Beyond HIF-1 alpha The hypoxia inducible factors are a family of heterodimeric transcription factors which are activated in response to lowered oxygen levels, or hypoxia. Although it may seem that HIF-1 alpha receives all the attention, other HIF antibodies, such as the...    Read more.

HIF Prolyl Hydroxylase 2: an important Oxygen Sensor Protein Prolyl hydroxylase domain (PHD) proteins, including PHD1, PHD2, and PHD3, mediate oxygen-dependent degradation of hypoxia-inducible factor (HIF) alpha subunits. Suppression of PHD enzymes leads to stabilization of HIFs and offers a potential treatment...    Read more.

HIF-3 alpha: a versatile target with hypoxia dependent and independent functions By: Subhash GangarHIF-3 alpha (hypoxia-inducible factor 3-alpha/ HIF3A) represents an isoform of HIF-alpha subunits which heterodimerize with stable beta subunit (HIF-beta) for the regulation of HIF target genes through binding to hypoxia respon...    Read more.

Read more HIF-3 alpha related blogs.