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Brain Concussion: Disease Bioinformatics

A brain concussion, also known as a mild traumatic brain injury, occurs when the brain experiences a major force, whether it is an impact force, in which the head experiences a direct blow, or an impulse force, in which the head snaps in one direction without a direct blunt trauma. The brain is surrounded by cerebrospinal fluid, and a large acceleration of the brain can overcome this protective layer and result in impaired neurotransmission and a reduction in cellular metabolism and cerebral blood flow. Fortunately, however, very few concussions result in neuronal cell loss. Symptoms of a concussion are headaches, nausea and vomiting, dilated pupils, confusion, and occasionally a loss of consciousness. These symptoms can last as little as 15 minutes, but the patient still needs careful monitoring for at least several hours after the injury to ensure that the blood loss was not too severe, in which case the patient would require medical attention. The only form of treatment of a concussion is physical and cognitive rest, unless the injury is severe enough to require surgery. Once a patient experiences a concussion, they become more susceptible to subsequent brain injuries.

Top Research Reagents

We have 3135 products for the study of Brain Concussion that can be applied to Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits.

Caspase-1 Antibody (14F468) - BSA Free

NB100-56565

Simple Western lane view shows a specific band for Caspase 1 in 1.0 mg/ml of HeLa lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system.

Activity of Casp1 in OHT-injured and normotensive control eyes. (A) Casp1 was detected by intraocular injection FLICA660-labeled substrate (green) in vivo 24 h after injury. Bright labeling (arrows) is evident in cells in the GCL and inner nuclear layer (INL) layers of the OHT-challenged retinas, a diffuse labeling of cell processes located in the IPL. Casp1 activity is diminished in Panx1-/- (Px1-/- OHT) retinas and WT retinas treated with probenecid (WT/Pbcd) at 12 h postinjury. Image collected and cropped by CiteAb from the following publication (https://www.frontiersin.org/article/10.3389/fnmol.2019.00036/full), licensed under a CC-BY license.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, Simple Western, ICC/IF

72 Publications

Enolase 2/Neuron-specific Enolase Antibody

NB110-58870

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, Simple Western, ICC/IF

2 Reviews

5 Publications

Carboxylesterase 2/CES2 Antibody

NBP1-84556

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC

1 Publication

CRAT Antibody

NBP1-86616

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

2 Publications

Carbonic Anhydrase I/CA1 Antibody

NBP1-88191

$Western Blot: Carbonic Anhydrase I/CA1 Antibody [NBP1-88191] - Comparative proteome analysis of 3xTg-AD and control samples at different stages of AD. Immunoblot analysis of most regulated hits. Soluble fractions of brain proteins were analyzed from four 2-month-old control and 3xTg-AD mice animals, respectively. Hebp1 and Glo1 levels were consistently elevated in the transgenic animals as compared to wild type controls. Ca1 levels were reduced in transgenic animals. Image collected and cropped by CiteAb from the following publication (https://elifesciences.org/articles/47498), licensed under a CC-BY license.$