Epilepsy is defined as a diverse set of neurological disorders characterized by seizures. These seizures occur due to abnormal electrical activity in the brain. Factors that may lead to epilepsy include, but are not limited to, brain trauma, gene mutations, strokes, brain cancer, and extensive drug and alcohol use. Seizures occur due to a large release of glutamate, which causes a spread of excitation throughout the brain, which propagates the electrical signal and can lead to neuronal death. Benign neonatal epilepsy is a rare autosomal dominant form of epilepsy, which is caused by mutations in the KCNQ2 and KCNQ3 genes, as well as by a chromosomal inversion. Seizures typically occur in newborns during their first seven days of life, and spontaneously stop within fifteen weeks. The child’s susceptibility to seizures is increased to 16%, compared to 2% of normal children, but there are no other side effects. About 50 million people have epilepsy, with 80% of that population located in developing countries. It is possible to control epilepsy with medicine, but many cases may require surgery in order to relieve symptoms.
Top Research Reagents
We have 902 products for the study of Benign Neonatal Epilepsy that can be applied to Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits.
![Western Blot: Sodium Potassium ATPase Alpha 2 Antibody (JE34-00) [NBP3-32061] - Western blot analysis of Sodium Potassium ATPase Alpha 2 on different lysates with Rabbit anti-Sodium Potassium ATPase Alpha 2 antibody (NBP3-32061) at 1/1,000 dilution.<br/><br/> Lane 1: Mouse heart tissue lysate<br/> Lane 2: Rat heart tissue lysate<br/><br/> Lysates/proteins at 30 ug/Lane.<br/><br/> Predicted band size: 112 kDa<br/> Observed band size: 100 kDa<br/><br/> Exposure time: 24 seconds;<br/><br/> 4-20% SDS-PAGE gel.<br/><br/> Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. The primary antibody (NBP3-32061) at 1/1,000 dilution was used in 5% NFDM/TBST at room temperature for 2 hours. Goat Anti-Rabbit IgG - HRP Secondary Antibody at 1:100,000 dilution was used for 1 hour at room temperature.](https://images.novusbio.com/fullsize/nbp3-32061_rabbit-sodium-potassium-atpase-alpha-2-mab-je34-00-278202416331215.jpg)
![Immunohistochemistry: Sodium Potassium ATPase Alpha 2 Antibody (JE34-00) [NBP3-32061] - Immunohistochemical analysis of paraffin-embedded human heart tissue with Rabbit anti-Sodium Potassium ATPase Alpha 2 antibody (NBP3-32061) at 1/1,000 dilution.<br/><br/> The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (NBP3-32061) at 1/1,000 dilution for 1 hour at room temperature. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX.](https://images.novusbio.com/fullsize/nbp3-32061_rabbit-sodium-potassium-atpase-alpha-2-mab-je34-00-298202413585522.jpg)
![Western Blot: Kv7.3 Antibody [NBP1-74102] - Lanes: 100 ug CHO cell lysate Primary Antibody Dilution: 1 : 1000 Secondary Antibody: Goat anti-rabbit HRP Secondary Antibody Dilution: 1 : 25000 Gene name: Kcnq3 Submitted by: Anonymous.](https://images.novusbio.com/fullsize/Kv7.3-Antibody-Western-Blot-NBP1-74102-img0004.jpg)
![Western Blot: Kv7.3 Antibody [NBP1-74102] - Kv7.3 Antibody Titration: 1.0 ug/ml Positive Control: Mouse Heart.](https://images.novusbio.com/fullsize/Kv7.3-Antibody-Western-Blot-NBP1-74102-img0003.jpg)
![Western Blot: PSMC1 Antibody [NBP1-80959] - Western blot analysis in mouse cell line NIH-3T3, rat cell line NBT-II and rat cell line pC12.](https://images.novusbio.com/fullsize/PSMC1-Antibody-Western-Blot-NBP1-80959-img0010.jpg)
![Immunocytochemistry/Immunofluorescence: PSMC1 Antibody [NBP1-80959] - Staining of human cell line U-2 OS shows localization to nucleoplasm & cytosol. Antibody staining is shown in green.](https://images.novusbio.com/fullsize/PSMC1-Antibody-Immunocytochemistry-Immunofluorescence-NBP1-80959-img0008.jpg)
![Immunocytochemistry/Immunofluorescence: Kv7.5 Antibody [NBP1-82861] - Staining of human cell line U-2 OS shows localization to vesicles. Antibody staining is shown in green.](https://images.novusbio.com/fullsize/Kv7.5-Antibody-Immunocytochemistry-Immunofluorescence-NBP1-82861-img0011.jpg)
![Immunohistochemistry-Paraffin: Kv7.5 Antibody [NBP1-82861] - Staining in human cerebral cortex and pancreas tissues using anti-KCNQ5 antibody. Corresponding KCNQ5 RNA-seq data are presented for the same tissues.](https://images.novusbio.com/fullsize/Kv7.5-Antibody-Immunohistochemistry-Paraffin-NBP1-82861-img0010.jpg)
![Immunocytochemistry/Immunofluorescence: PKC mu Antibody [NBP1-87789] - Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & cytosol.](https://images.novusbio.com/fullsize/PKC-mu-Antibody-Immunocytochemistry-Immunofluorescence-NBP1-87789-img0007.jpg)
![Immunohistochemistry-Paraffin: PKC mu Antibody [NBP1-87789] - Staining of human parathyroid gland shows cytoplasmic positivity in glandular cells.](https://images.novusbio.com/fullsize/PKC-mu-Antibody-Immunohistochemistry-Paraffin-NBP1-87789-img0006.jpg)
![Immunohistochemistry-Paraffin: Prostaglandin E Synthase Antibody [NBP1-87852] - Analysis in human seminal vesicle and pancreas tissues. Corresponding Prostaglandin E Synthase RNA-seq data are presented for the same tissues.](https://images.novusbio.com/fullsize/Prostaglandin-E-Synthase-Antibody-Immunohistochemistry-Paraffin-NBP1-87852-img0019.jpg)
![Immunocytochemistry/Immunofluorescence: Prostaglandin E Synthase Antibody [NBP1-87852] - Staining of human cell line SiHa shows localization to endoplasmic reticulum. Antibody staining is shown in green.](https://images.novusbio.com/fullsize/Prostaglandin-E-Synthase-Antibody-Immunocytochemistry-Immunofluorescence-NBP1-87852-img0010.jpg)
![Immunohistochemistry-Paraffin: Carbonic Anhydrase I/CA1 Antibody [NBP1-88191] - Analysis in human rectum and pancreas tissues. Corresponding CA1 RNA-seq data are presented for the same tissues.](https://images.novusbio.com/fullsize/Carbonic-Anhydrase-I-CA1-Antibody-Immunohistochemistry-Paraffin-NBP1-88191-img0010.jpg)
![Western Blot: Carbonic Anhydrase I/CA1 Antibody [NBP1-88191] - Comparative proteome analysis of 3xTg-AD and control samples at different stages of AD. Immunoblot analysis of most regulated hits. Soluble fractions of brain proteins were analyzed from four 2-month-old control and 3xTg-AD mice animals, respectively. Hebp1 and Glo1 levels were consistently elevated in the transgenic animals as compared to wild type controls. Ca1 levels were reduced in transgenic animals. Image collected and cropped by CiteAb from the following publication (https://elifesciences.org/articles/47498), licensed under a CC-BY license.](https://images.novusbio.com/fullsize/Carbonic-Anhydrase-I-CA1-Antibody-Western-Blot-NBP1-88191-img0015.jpg)
![Western Blot: Kv7.1 Antibody (S37A/10) [NBP2-12897] - Western Blot analysis of Human Cell lysates showing detection of Kv7.1 protein using Mouse Anti-Kv7.1 Monoclonal Antibody, Clone N37A/10 (NBP2-12897). Load: 15 ug. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Kv7.1 Monoclonal Antibody (NBP2-12897) at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT.](https://images.novusbio.com/fullsize/Kv7-1-Antibody-S37A-10-Western-Blot-NBP2-12897-img0010.jpg)
![Immunocytochemistry/Immunofluorescence: Kv7.1 Antibody (S37A/10) [NBP2-12897] - Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Kv7.1 Monoclonal Antibody, Clone N37A/10 (NBP2-12897). Tissue: Neuroblastoma cells (SH-SY5Y). Species: Human. Fixation: 4% PFA for 15 min. Primary Antibody: Mouse Anti-Kv7.1 Monoclonal Antibody (NBP2-12897) at 1:100 for overnight at 4C with slow rocking. Secondary Antibody: AlexaFluor 488 at 1:1000 for 1 hour at RT. Counterstain: Phalloidin-iFluor 647 (red) F-Actin stain; Hoechst (blue) nuclear stain at 1:800, 1.6mM for 20 min at RT. (A) Hoechst (blue) nuclear stain. (B) Phalloidin-iFluor 647 (red) F-Actin stain. (C) Kv7.1 Antibody (D) Composite.](https://images.novusbio.com/fullsize/Kv7-1-Antibody-S37A-10-Immunocytochemistry-Immunofluorescence-NBP2-12897-img0013.jpg)
![Western Blot: Kv7.4 Antibody (S43/6) [NBP2-12899] - Western Blot analysis of Rat tissue lysate showing detection of Kv7.4 protein using Mouse Anti-Kv7.4 Monoclonal Antibody, Clone N43/6 (NBP2-12899). Load: 15 ug. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Kv7.4 Monoclonal Antibody (NBP2-12899) at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT.](https://images.novusbio.com/fullsize/Kv7-4-Antibody-S43-6-Western-Blot-NBP2-12899-img0008.jpg)
![Immunocytochemistry/Immunofluorescence: Kv7.4 Antibody (S43/6) [NBP2-12899] - Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Kv7.4 Monoclonal Antibody, Clone N43/6 (NBP2-12899). Tissue: Neuroblastoma cells (SH-SY5Y). Species: Human. Fixation: 4% PFA for 15 min. Primary Antibody: Mouse Anti-Kv7.4 Monoclonal Antibody (NBP2-12899) at 1:100 for overnight at 4C with slow rocking. Secondary Antibody: AlexaFluor 488 at 1:1000 for 1 hour at RT. Counterstain: Phalloidin-iFluor 647 (red) F-Actin stain; Hoechst (blue) nuclear stain at 1:800, 1.6mM for 20 min at RT. (A) Hoechst (blue) nuclear stain. (B) Phalloidin-iFluor 647 (red) F-Actin stain. (C) Kv7.4 Antibody (D) Composite.](https://images.novusbio.com/fullsize/Kv7-4-Antibody-S43-6-Immunocytochemistry-Immunofluorescence-NBP2-12899-img0010.jpg)
![Immunohistochemistry: POMC Antibody [NB100-1533] - Representative confocal images of POMC in POMC-transfected WT and Sel1L-/- N2a cells. White arrows point to POMC-containing secretory granules, while yellow arrows point to perinuclear POMC. KDEL marks the ER. Representative data from at least 2 independent experiments are shown. Image collected and cropped by CiteAb from the following publication (jci.org/articles/view/96420), licensed under a CC-BY license.](https://images.novusbio.com/fullsize/POMC-Antibody-Immunohistochemistry-NB100-1533-img0008.jpg)
![Flow Cytometry: POMC Antibody [NB100-1533] - Flow cytometric analysis of paraformaldehyde fixed A431 cells (blue line), permeabilized with 0.5% Triton. Primary incubation 1hr (10 ug/mL) followed by Alexa Fluor 488 secondary antibody (1 ug/mL). IgG control: Unimmunized goat IgG (black line) followed by Alexa Fluor 488 secondary antibody.](https://images.novusbio.com/fullsize/POMC-Antibody-Flow-Cytometry-NB100-1533-img0006.jpg)
![Immunocytochemistry/Immunofluorescence: Kv7.2 Antibody [NBP2-38820] - Immunofluorescent staining of human cell line SH-SY5Y shows localization to endoplasmic reticulum.](https://images.novusbio.com/fullsize/Kv7.2-Antibody-Immunocytochemistry-Immunofluorescence-NBP2-38820-img0003.jpg)
![Immunohistochemistry-Paraffin: Kv7.2 Antibody [NBP2-38820] - Staining of human pancreas shows low expression as expected.](https://images.novusbio.com/fullsize/Kv7.2-Antibody-Immunohistochemistry-Paraffin-NBP2-38820-img0005.jpg)
![Western Blot: Nicotinic Acetylcholine R alpha 4/CHRNA4 Antibody (7B4H1) [NBP2-61674] - Analysis using CHRNA4 mAb against HEK293 (1) and CHRNA4 (AA: 29-242)-hIgGFc transfected HEK293 (2) cell lysate.](https://images.novusbio.com/fullsize/Nicotinic-Acetylcholine-R-alpha-4-CHRNA4-Antibody-7B4H1-Western-Blot-NBP2-61674-img0003.jpg)
![Flow Cytometry: Nicotinic Acetylcholine R alpha 4/CHRNA4 Antibody (7B4H1) [NBP2-61674] - Analysis using CHRNA4 mouse mAb against SH-SY5Y (1) cell lysate.](https://images.novusbio.com/fullsize/Nicotinic-Acetylcholine-R-alpha-4-CHRNA4-Antibody-7B4H1-Flow-Cytometry-NBP2-61674-img0004.jpg)
![Western Blot: PRRT2 Antibody [NBP2-82026] - Analysis of PRRT2 in mouse brain tissue lysate with PRRT2 antibody at 1 ug/ml.](https://images.novusbio.com/fullsize/PRRT2-Antibody-Western-Blot-NBP2-82026-img0001.jpg)
![Immunocytochemistry/Immunofluorescence: PRRT2 Antibody [NBP2-82026] - Immunofluorescence of PRRT2 in rat brain tissue with PRRT2 antibody at 20 ug/ml.](https://images.novusbio.com/fullsize/PRRT2-Antibody-Immunocytochemistry-Immunofluorescence-NBP2-82026-img0003.jpg)
![Immunohistochemistry: Kv1.1 Antibody [NBP3-03729] - Analysis of mouse brain using Kv1.1 antibody at dilution of 1:100. Blue: DAPI for nuclear staining.](https://images.novusbio.com/fullsize/Kv1.1-Antibody-Immunohistochemistry-NBP3-03729-img0001.jpg)
![Western Blot: SCN1B Antibody [NBP2-94559] - Analysis of extracts of various cell lines, using SCN1B at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit . Exposure time: 60s.](https://images.novusbio.com/fullsize/SCN1B-Antibody-Western-Blot-NBP2-94559-img0001.jpg)
