WHSC2 Products

Description

WHSC2 is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation. [provided by RefSeq]

Bioinformatics

Entrez	7469 Human
Uniprot	BAB18651.1 Human NP_005654 Human
Product By Gene ID	7469
Alternate Names	FLJ10442 negative elongation factor A NELFA NELF-AFLJ25112 Wolf-Hirschhorn syndrome candidate 2 protein Wolf-Hirschhorn syndrome candidate 2

Research Areas for WHSC2

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Cancer