USP4 Products

Description

Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.

Bioinformatics

Entrez	7375 Human
Uniprot	AAB72237.1 Human NM_003363 Human NP_003354 Human NP_003354. Human NP_003354.2 Human Q13107 Human UBP4_HUMAN Human
Product By Gene ID	7375
Alternate Names	Deubiquitinating enzyme 4 EC 3.1.2.15 EC 3.4.19.12 MGC149848 MGC149849 ubiquitin carboxyl-terminal esterase 4 ubiquitin carboxyl-terminal hydrolase 4 ubiquitin specific peptidase 4 (proto-oncogene) ubiquitin specific protease 4 (proto-oncogene) ubiquitin thioesterase 4 Ubiquitin thiolesterase 4 ubiquitin-specific processing protease 4 Ubiquitin-specific-processing protease 4 Ubiquitous nuclear protein homolog UNPH UNPUnph