USP18 Products

Description

UBP43 (also known as ISG43, Ubl thiolesterase 18, ISG15-specific processing protease, 43 kDa ISG15-specific protease, ubiquitin specific protease 18 or USP18) is a member of the deubiquitinating protease family of enzymes, which removes ubiquitin adducts from a broad range of protein substrates. Deletion of the UBP43 gene in mouse leads to a massive increase of ISG15 conjugates in tissues indicating that UBP43 is a major ISG15-specific protease. UBP43 is the first ISG15-specific protease reported. Both ISG15 and UBP43 genes are known to be strongly induced by interferon, genotoxic stress, and viral infection. Thus UBP43 may be necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms.

Bioinformatics

Entrez	11274 Human
Uniprot	AAH14896 Human CAK54503.1 Human NM_017414 Human NP_059110 Human NP_059110.2 Human Q9UMW8 Human
Product By Gene ID	11274
Alternate Names	EC 3.1.2.15 EC 3.4.19.- hUBP43 ISG15-specific-processing protease ISG43UBP43 ubiquitin specific peptidase 18 ubiquitin specific protease 18 ubl carboxyl-terminal hydrolase 18 ubl thioesterase 18,43 kDa ISG15-specific protease Ubl thiolesterase 18

Research Areas for USP18

Find related products by research area and learn more about each of the different research areas below.

Cell Biology
Neuroscience
Ubiquitin Proteasome Pathway