UCP2 Products

Description

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'.

Bioinformatics

Entrez	22228 Mouse 54315 Rat 7351 Human
Uniprot	AAH11737 Human AAH11737.1 Human NM_003355 Human NP_003346 Human NP_003346.2 Human P55851 Human
Product By Gene ID	7351
Alternate Names	mitochondrial uncoupling protein 2 SLC25A8BMIQ4 Solute carrier family 25 member 8 UCP 2 UCPH uncoupling protein 2 (mitochondrial, proton carrier)