Species: Hu, Mu
Applications: WB, ELISA, ICC/IF, IHC
Host: Mouse Monoclonal
Species: Hu, Mu, Rt
Applications: WB, ELISA, IHC, IP
Host: Rabbit Polyclonal
Species: Hu
Applications: ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome.
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
|
| Product By Gene ID |
197131 |
| Alternate Names |
- E3 ubiquitin-protein ligase UBR1
- E3a ligase
- EC 6.3.2.-
- JBS
- MGC142065
- MGC142067
- N-recognin-1
- ubiquitin ligase E3 alpha-I
- ubiquitin protein ligase E3 component n-recognin 1
- ubiquitin-protein ligase E3-alpha
- Ubiquitin-protein ligase E3-alpha-1
- Ubiquitin-protein ligase E3-alpha-I
|
