TRIM21/SSA1 Products

Description

SSA1 encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined.

Bioinformatics

Entrez	6737 Human
Uniprot	AAH10861 Human NM_003141 Human NP_003132 Human NP_003132. Human NP_003132.2 Human P19474 Human
Product By Gene ID	6737
Alternate Names	52 kDa ribonucleoprotein autoantigen Ro/SS-A 52 kDa Ro/SSA E3 ubiquitin-protein ligase TRIM21 EC 6.3.2.- rhTRIM21 RNF81RING finger protein 81 Ro(SS-A) ro(SS-A) RO52SS-A Sicca syndrome antigen A Sjoegren syndrome type A antigen Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro) SSA1SSA tripartite motif containing 21,52 kDa Ro protein tripartite motif-containing 21 Tripartite motif-containing protein 21

Research Areas for TRIM21/SSA1

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Zinc Finger