TPSD1 Products

Description

Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. Although this gene may be an exception, most of the tryptase genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. This gene was once considered to be a pseudogene, although it is now believed to be a functional gene that encodes a protein. [provided by RefSeq]

Bioinformatics

Entrez	23430 Human
Uniprot	NP_036349.1 Human Q9BZJ3 Human
Product By Gene ID	23430
Alternate Names	delta-tryptase Delta-tryptase EC 3.4.21 EC 3.4.21.59 HmMCP-3-like tryptase III Mast cell mMCP-7-like mast cell tryptase MCP7L1 MCP7-LIKE MGC95428 MMCP-7L mMCP-7-like delta II tryptase mMCP-7-like-1 mMCP-7-like-2 tryptase delta 1 tryptase delta tryptase-3 Tryptase-3