TBL1 Products

Description

TBL1 is encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. This gene is highly similar to the Y chromosome TBL1Y gene.

Bioinformatics

Entrez	6907 Human
Uniprot	AAH32708.1 Human NP_001132938 Human NP_005638 Human NP_005638. Human NP_005638.1 Human NP_078941.2 Human
Product By Gene ID	6907
Alternate Names	EBI SMAP55 TBL1transducin (beta)-like 1 transducin (beta)-like 1X-linked X-linked

Research Areas for TBL1

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Wnt Signaling Pathway