STAT1 Products

Description

STATs (signal transducers and activators of transcription) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STATs enter the nucleus to regulate transcription of many different genes. Among the seven STATs (Stat1, Stat2, Stat3, Stat4, Stat5a, Stat5b, and Stat6), Stat1, Stat3, Stat5a, and Stat5b have a wide activation profile. STAT1 is activated by many different ligands including IFN family (IFN-a, IFN-b, IFN-g and IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, and G-CSF), and receptor tyrosine kinases (EGF, PDGF, and CSF-1). STAT1 has two forms, the 91 kDa STAT1a and the 84 kDa STAT1b which are encoded by the same gene with splicing variant.

Bioinformatics

Entrez	20846 Mouse 25124 Rat 6772 Human
Uniprot	AAH02704 Human AAH02704.1 Human NM_139266 Human NP_009330 Human NP_644671 Human P42224 Human
Product By Gene ID	6772
Alternate Names	DKFZp686B04100 ISGF-3,91kD signal transducer and activator of transcription 1, 91kDa signal transducer and activator of transcription-1

Research Areas for STAT1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Breast Cancer
Cancer
Phospho-Specific
Signal Transduction
Transcription Factors and Regulators

Related STAT1 Blog Posts

Check out the latest blog posts on STAT1.

Using a STAT3 antibody in chromatin immunoprecipitation (ChIP) Signal transducer and activator of transcription 3 (STAT3) is an important oncogenic transcriptional factor that mediates tumor induced immune suppression.  Specifically, STAT3 transmits signals from cytokines and growth factor receptors in the pla...    Read more.

Signal Transducer and Activator of Transcription STAT6: More than a Player in Allergic Inflammation By Jamshed Arslan, Pharm. D., PhD. What is STAT6?The cellular pathway comprising tyrosine kinase Janus Kinase (JAK) and the transcription factor STAT connect extracellular signals from various cytokines, hormones an...    Read more.

Read more STAT1 related blogs.