Species: Hu, Mu, Rt
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
Species: Hu, RM
Applications: WB, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, IP
Host: Rabbit Monoclonal
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
The p190 Rho GTPase activating protein RhoGAP) family includes two closely related proteins, p190-A and p190-B. p190-B contains an N-terminal GTPase domain and a C-terminal Rho-GAP domain (1). p190-B can be directly phosphorylated on a single identified tyrosine residue by the activated insulin and IGF-1 receptors. This phosphorylation causes p190-B to translocate to the lipid rafts of the plasma membrane, where it can facilitate the inactivation of the Rho GTPase. P190-B also has been shown to be tyrosine phosphorylated by c-Src and v-Src. Additionall; the GAP domain of p190-B as shown to attenuate signal-transducing activity of Rac, Rho and CDC42 (2-3).
Bioinformatics
| Entrez |
Mouse
Rat
Human
|
| Uniprot |
Human
Human
|
| Product By Gene ID |
394 |
| Alternate Names |
- growth factor independent 2
- p100 RasGAP-associated p105 protein
- p105 RhoGAP
- p190-BGFI2
- p190BRhoGAP
- Rho GTPase activating protein 5
- rho GTPase-activating protein 5
- RHOGAP5
- RhoGAP5
- Rho-type GTPase-activating protein 5
|
