REXO1 Products

Description

REXO1 or Elongin A-binding protein 1 (EloA-BP1) is an exonuclease domain-containing protein that can bind to Elongin. The Elongin complex stimulates the rate of transcription elongation by RNA polymerase II by suppressing the transient pausing of the polymerase at many sites along the DNA template. REXO1 is composed of 1221 amino acids and its mRNA is ubiquitously expressed. EloA-BP1 is capable of binding not only the NH(2)-terminal approximately 120 amino acid region of Elongin A, but also that of SII. Although REXO1 had no detectable effect on the rate of transcription elongation in vitro, it may play some role in the regulation of elongation in vivo.

Bioinformatics

Entrez	314630 Rat 57455 Human 66932 Mouse
Uniprot	NP_065746 Human Q8N1G1 Human
Product By Gene ID	57455
Alternate Names	EC 3.1 ELOABP1elongin A-binding protein 1 EloA-BP1REX1 Elongin-A-binding protein 1 KIAA1138elongin A binding protein 1 REX1, RNA exonuclease 1 homolog (S. cerevisiae) TCEB3BP1RNA exonuclease 1 homolog transcription elongation factor B polypeptide 3 binding protein 1 Transcription elongation factor B polypeptide 3-binding protein 1

Research Areas for REXO1

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DNA Repair
Editing and Processing Endonucleases