Ret Products

Description

Ret, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed.

Bioinformatics

Entrez	19713 Mouse 24716 Rat 5979 Human
Uniprot	AAH03072 Human AAH04257.1 Human NP_066124 Human P07949 Human
Product By Gene ID	5979
Alternate Names	CDHF12MTC1 CDHR16 EC 2.7.10 Hirschsprung disease 1 Hirschsprung disease) MEN2A MEN2B multiple endocrine neoplasia and medullary thyroid carcinoma 1 ret proto-oncogene RET transforming sequence

Research Areas for Ret

Find related products by research area and learn more about each of the different research areas below.

Cancer
Phospho-Specific
Protein Kinase
Protein Phosphatase
Signal Transduction
Tumor Suppressors

Related Ret Blog Posts

Check out the latest blog posts on Ret.

Beta III tubulin The Beta III tubulin protein is abundantly present in both the central and peripheral nervous systems (CNS and PNS), where it is predominantly expressed during fetal and postnatal development. In cerebellar and sympathoadrenal neurogenesis, Beta III d...    Read more.

Untangling the contribution of the enteric nervous system to intestinal and extraintestinal disease By Emily Cartwright, PhD What is the ENS?When it's late in the afternoon and you smell a delicious bag of popcorn in the microwave, your mouth begins to water and your stomach starts to grumble. These behaviors ar...    Read more.

Successful Transplantation of Friedreich Ataxia Induced Pluripotent Stem Cell (iPSC)-Derived Sensory Neurons in Dorsal Root Ganglia of Adult Rodents Jamshed Arslan, Pharm D, PhD The dorsal root ganglia (DRG) are a collection of cell bodies of sensory nerves carrying sensory information – including nociception, mechanoreception and proprioception – from periphera...    Read more.

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