Species: Hu, Mu, Rt, Bv, Ch, Dr, RM, Xp, Ze
Applications: WB, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, ELISA, IHC
Host: Goat Polyclonal
Species: Hu
Applications: WB, ELISA, ICC/IF
Host: Mouse Monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: PAGE
Species: Hu
Applications: PAGE
Description
RAC2 is a plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, RAC2 binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. There are two isoforms of RAC2; isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction.
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
Human
Human
Human
|
| Product By Gene ID |
5880 |
| Alternate Names |
- GX
- Gx
- HSPC022
- ras-related C3 botulinum toxin substrate 2 (rho family, small GTP bindingprotein Rac2)
- rho family, small GTP binding protein Rac2
- small GTP-bindingprotein Rac2)
|
