Rab5a Products

Description

Rab5 is a 24 kDa GTP-binding protein that regulates the fusion of plasma membrane -derived clathrin-coated vesicles with early endosomes , and homotypic fusion among early endosomes1. Localized to the cytoplasmic side of the plasma membrane, clathrin -coated vesicles and early endosomes, Rab5 appears to regulate vesicle fusion through a cycle of GDP/GTP e xchange and GTP hydrolysis. The different guanine nuc leotide binding states of Rab5 may affect its ability to associate or dissociate with membranes during endocytotic membrane traffic. The GTP-bound, or active, form of Rab5 associates with membrane s and regulates vesicle docking and fusion. Studies using a Rab5 mutant that hydrolyzed xanthosine 5 -triphosphate (XTP) indicated that nucleotide hydrolysis occurs even in the absence of membrane fusion. GTP hydrolysis by Rab5 may determine the frequency of membrane docking and fusion events.

Bioinformatics

Entrez	271457 Mouse 5868 Human 64633 Rat
Uniprot	AAH01267 Human AAH18288 Human NM_004162 Human NP_004153 Human P20339 Human Q6FI44 Human
Product By Gene ID	5868
Alternate Names	RAB5A, member RAS oncogene family RAB5RAS-associated protein RAB5A ras-related protein Rab-5A

Research Areas for Rab5a

Find related products by research area and learn more about each of the different research areas below.

Endosome Markers
Signal Transduction