Presenilin-1 Products

Description

Presenilin (PS) facilitates gamma-secretase cleavage of the beta-amyloid precursor protein and the intramembraneous cleavage of Notch1 (1). Presenilin (PS) is essential for the gamma-cleavage required for the generation of the C terminus of amyloid beta-protein (Abeta). The discovery that a deficiency of presenilin 1 (PS1) decreases the production of amyloid beta-protein (Abeta) identified the presenilins as important mediators of the gamma-secretase cleavage of beta-amyloid precursor protein (APP). It has been shown that two conserved transmembrane (TM) aspartates in PS1 are critical for Abeta production, providing evidence that PS either functions as a required diaspartyl cofactor for gamma-secretase or is itself gamma-secretase. Presenilin 2 (PS2) shares substantial sequence and possibly functional homology with PS1. It has been shown that the two TM aspartates in PS2 are also critical for gamma-secretase activity, providing further evidence that PS2 is functionally homologous to PS1 (2). PS are found primarily within intracellular membranes, including the endoplasmic reticulum (ER) and the trans-Golgi network as well as the plasma membrane. PS are also expressed in most cell types throughout development (3).

Bioinformatics

Entrez	19164 Mouse 29192 Rat 5663 Human
Uniprot	AAH11729 Human NM_000021 Human NP_000012 Human P49768 Human PSN1_HUMAN Human
Product By Gene ID	5663
Alternate Names	AD3EC 3.4.23.- Alzheimer disease 3 EC 3.4.23 FAD presenilin 1 Protein S182 PS-1 PS1presenilin-1 PSNL1 S182

Research Areas for Presenilin-1

Find related products by research area and learn more about each of the different research areas below.

Alzheimers Research
Apoptosis
Cancer
Hematopoietic Stem Cell Markers
Neurodegeneration
Neuronal Cell Markers
Neuroscience
Neurotransmission
Phospho-Specific
Stem Cell Markers
Stem Cell Signaling Pathway
Tumor Suppressors
Wnt Signaling Pathway

Related Presenilin-1 Blog Posts

Check out the latest blog posts on Presenilin-1.

Immunity’s flipside: Microglia promote Alzheimer’s pathology during inflammation By Jamshed Arslan Pharm.D. Microglia are brain's macrophages. In Alzheimer's disease (AD), microglia clear up protein aggregates called amyloid beta plaques. The connection between immune activation and AD is unclea...    Read more.

Mechanisms of Neurodegeneration: Protein aggregation and failure of autophagy By Michalina Hanzel, PhDIn a series of three blog posts I will briefly explore the major cellular mechanisms responsible for many neurodegenerative disorders. The first, and perhaps the most apparent, is the accumulat...    Read more.

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