PPAR alpha/NR1C1 Products

Description

Peroxisome proliferators are non-genotoxic carcinogens which are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family, termed peroxisome proliferator activated receptors (PPARs). Nuclear hormone receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. Studies indicate that PPARs are activated by peroxisome proliferators such as clofibric acid, nafenopin, and WY-14,643, as well as by some fatty acids. It has also been shown that PPARs can induce transcription of acyl coenzyme A oxidase & cytochrome P450 A6 (CYP450 A6) through interaction with specific response elements. PPAR alpha is activated by free fatty acids including linoleic, arachidonic, and oleic acids. Induction of peroxisomes by this mechanism leads to a reduction in blood triglyceride levels. PPAR alpha is expressed mainly in skeletal muscle, heart, liver, and kidney and is thought to regulate many genes involved in the beta-oxidation of fatty acids. Activation of rat liver PPAR alpha has been shown to suppress hepatocyte apoptosis. PPAR alpha, like several other nuclear hormone receptors, heterodimerizes with retinoic X receptor (RXR) alpha to form a transcriptionally competent complex. The corresponding gene for the PPAR alpha is NR1C1.

Bioinformatics

Entrez	19013 Mouse 25747 Rat 5465 Human
Uniprot	NM_005036 Human NP_001001928 Human NP_001001928.1 Human P23204 Mouse Q07869 Human
Product By Gene ID	5465
Alternate Names	alpha hPPAR NR1C1MGC2237 Nuclear receptor subfamily 1 group C member 1 peroxisome proliferator-activated receptor alpha PPARalpha PPAR-alpha PPARMGC2452

Research Areas for PPAR alpha/NR1C1

Find related products by research area and learn more about each of the different research areas below.

Cancer
Lipid and Metabolism
mTOR Pathway
Phospho-Specific
Transcription Factors and Regulators