PKC theta Products

Description

Members of the protein kinase C (PKC) family play a key regulatory role in variety of cellular functions including cell growth and differentiation, gene expression, hormone secretion and membrane function. PKCs were originally identified as serine/threonine protein kinases whose activity was dependent on calcium and phospholipids. Diacylglycerols (DAG) and tumor promoting phorbol esters bind to and activate PKC. PKCs can be subdivided into at least two major classes including conventional (c) PKC isoforms (alpha, betaI, betaII and gamma) and novel (n) PKC isoforms (delta, episilon , zeta, eta and theta). Patterns of expression for each PKC isoform differs among tissues and PKC family members exhibit clear differences in their cofactor dependencies. For instance, the kinase activities of nPKC delta and episilon are independent of Ca++. On the other hand, nPKC and episilon, as well as all of the cPKC members, possess phorbol ester-binding activities and kinase activities.

Bioinformatics

Entrez	18761 Mouse 5588 Human 85420 Rat
Uniprot	NM_006257 Human NP_006248 Human NP_006248.1 Human Q04759 Human
Product By Gene ID	5588
Alternate Names	EC 2.7.11 EC 2.7.11.13 MGC126514 MGC141919 nPKC-theta PRKCT protein kinase C theta type protein kinase C, theta

Research Areas for PKC theta

Find related products by research area and learn more about each of the different research areas below.

Phospho-Specific
Protein Kinase
Signal Transduction