PKC gamma Products

Description

Protein Kinase C gamma (PKC gamma) is an 80 kDa member of the conventional group (cPKCs: sensitive to calcium, diacylglycerol, phosphotidylserine and phorbol esters) of the PKC family of serine/threonine kinases that are involved in a wide range of physiological processes including mitogenesis, cell survival and transcriptional regulation. PKC gamma plays a key role in neuronal signal transduction and in regulating intercellular communication. The activation loop threonine (threonine 514 in PKC gamma) of conventional PKCs is phosphorylated by phosphoinositide-dependent kinase-1 (PDK1), which is necessary for its autophosphorylation on threonine 655 in the turn loop, and threonine 674 in the hydrophobic loop of the carboxy terminus, a critical step in generating a catalytically mature enzyme. The phosphorylation of the hydrophobic loop in the carboxyl terminus of PKCs is believed to be a key determinant in regulating PKC interaction with PDK1.

Bioinformatics

Entrez	18752 Mouse 24681 Rat 5582 Human
Uniprot	AAH47876 Human NM_002739 Human NM_002739. Human NM_002739.3 Human P05129 Human P63318 Mouse P63319 Rat
Product By Gene ID	5582
Alternate Names	EC 2.7.11 EC 2.7.11.13 MGC57564 PKCCSCA14 PKC-gamma PKCGprotein kinase C gamma type protein kinase C, gamma

Research Areas for PKC gamma

Find related products by research area and learn more about each of the different research areas below.

Phospho-Specific
Protein Kinase
Signal Transduction
Wnt Signaling Pathway