PITRM1 Products

Description

ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference

Bioinformatics

Entrez	10531 Human
Uniprot	AAH01150 Human AAH95422.1 Human NP_055704 Human
Product By Gene ID	10531
Alternate Names	EC 3.4.24 EC 3.4.24.- hPreP Metalloprotease 1 MGC138192 MGC141929 pitrilysin metallopeptidase 1 Pitrilysin metalloproteinase 1mitochondrial PreP