PICK1 Products

Description

PSD-95/DLG/ZO-1 (PDZ) domain-containing proteins play a central role in synaptic membrane protein localization. The protein interacting with protein kinase C (PICK 1) is a synaptic PDZ domain protein that also contains a coiled-coil and acidic domain. Studies indicate that PICK 1 functions as a targeting and transport protein and has been shown to interact with protein kinase C alpha (PKC alpha), AMPA-type glutamate receptors, and several other membrane receptors via its PDZ domain. The interaction of PICK 1 with PKC alpha is highly dependent on the activation of the kinase. It appears that PICK 1 directs the activated form of PKC alpha to membrane anchored GluR2. Once phosphorylated by PKC alpha, GluR2 is released from the synaptic anchor proteins. Once released, GluR2 is transported from the synaptic membrane in a PICK 1-dependent manner.

Bioinformatics

Entrez	18693 Mouse 84591 Rat 9463 Human
Uniprot	NM_001039583 Human NP_001034673 Human NP_036539 Human NP_036539.1 Human Q9EP80 Rat Q9NRD5 Human
Product By Gene ID	9463
Alternate Names	alpha binding protein dJ1039K5 MGC15204 PICK PRKCA-binding protein PRKCABPprotein interacting with PRKCA Protein interacting with C kinase 1 protein interacting with PRKCA 1 Protein kinase C-alpha-binding protein

Research Areas for PICK1

Find related products by research area and learn more about each of the different research areas below.

Signal Transduction
Transcription Factors and Regulators
Vision