PDE1A Products

Description

PDE1A, a variant of PDE1, is a Ca2+-calmodulin-stimulated phosphodieterase (PDE) preferentially hydrolyzing cGMP. Cyclic nucleotides are hydrolyzed and compartmentalized by a family of enzymes called phosphodieterases. In mammals at least 11 different families of PDEs can be discriminated (PDE1-11) based on their kinetic properties and inhibition to various pharmacological agents. Three different PDE1 genes have been identified (PDE1A, B, and C). PDE1A and PDE1B have higher affinity for cGMP than for cAMP, whereas PDE1C has high affinity for both cAMP and cGMP. The PDE1A gene family includes various proteins that differ from each other at amino and carboxy termini of the protein.

Bioinformatics

Uniprot	NM_005019 Human NP_005010 Human NP_005010.2 Human P54750-4 Human
Product By Gene ID	5136
Alternate Names	3'-5' cyclic nucleotide phosphodiesterase 61 kDa Cam-PDE calcium/calmodulin-dependent 3'-5'-cyclic nucleotide phosphodiesterase 1A calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase calmodulin-dependent phosphodiesterase Cam-PDE 1A EC 3.1.4 EC 3.1.4.17 HCAM1 hCam-1 HSPDE1A MGC26303 phosphodiesterase 1A, calmodulin-dependent phosphodiesterase-1A