Species: Hu, Mu, Rt, Ze, Po, Bv
Applications: WB, ICC/IF, IHC, IP
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt, Po, Bv, Ze
Applications: WB, IHC, IP
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, ELISA, IHC
Host: Mouse Monoclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, ICC/IF, MA, AP
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: WB, ELISA, MA, AP
Description
Valosin-containing protein (VCP or p97) belongs to the AAA (ATPase associated activities) family and acts as a molecular chaperone to a wide variety of cellular activities. Some of these activities include the alteration of both nuclear and mitotic golgi membranes, ubiquitin-proteasome dependent protein degradation, regulation of the NF-kappa b pathway, and extraction of membrane proteins. VCP has been shown to contain a substrate binding domain (N) and two conserved ATPase domains (D1 and D2). The three dimensional structure of VCP resembles that of a cylinder with the D1 and D2 stacked upon one another in a homo-hexameric ring formation. VCP is involved in the formation of neuronal inclusion bodies in neurodegenerative disease such as Parkinson's Disease.
Bioinformatics
| Uniprot |
Human
Human
Human
Human
Human
Human
|
| Product By Gene ID |
7415 |
| Alternate Names |
- 15S Mg(2+)-ATPase p97 subunit
- IBMPFDMGC8560
- MGC131997
- p97
- TER ATPase
- TERA
- transitional endoplasmic reticulum ATPase
- valosin containing protein
- Valosin-containing proteinMGC148092
- yeast Cdc48p homolog
|
