NCOA3/AIB1 Products

Description

NCOA3/SRC3 (nuclear receptor coactivator 3/steroid receptor coactivator 3 (SRC3)) is a 155 kD member of the p160/steroid receptor coactivator family containing a nuclear localization sequence, bHLH, and PAS domain. There are two reported isoforms of this protein. NCOA3/SRC3 is localized mainly in the cytoplasm, with weak nuclear expression. The protein is translocated to the nucleus upon phosphorylation. NCOA3/SRC3 is widely expressed with high expression in the heart, skeletal muscle, pancreas, and placenta and low expression in the brain. NCOA3/SRC3 is expressed at very low levels in the lung, liver, and kidney and overexpressed in breast and ovarian cancers. This protein has histone acetyltransferase activity and functions as a transcriptional coactivator for steroid and nuclear hormone receptors. Phosphorylation by I kappaB kinase enhances coactivator function. Acetylation by CREB-BP disrupts interaction with nuclear receptors. NCOA3/SRC3 forms a multisubunit coactivation complex with NCOA2 IKKA, IKKB, IKBKG and histone acetyltransferase protein CREB binding protein and has also been shown to interact with PCAF.

Bioinformatics

Entrez	116833 Human 8202 Human
Uniprot	NM_006534 Human NP_006525 Human NP_858045 Human Q9Y6Q9 Human
Product By Gene ID	8202
Alternate Names	ACTRCBP-interacting protein AIB1AIB-1 Amplified in breast cancer 1 protein BHLHE42 bHLHe42p/CIP CAGH16 Class E basic helix-loop-helix protein 42 CTG26 KAT13B MGC141848 NCoA-3 nuclear receptor coactivator 3 pCIP RAC-3 RAC3pCIP Receptor-associated coactivator 3 SRC3 SRC-3EC 2.3.1.48 Steroid receptor coactivator protein 3 Thyroid hormone receptor activator molecule 1 TNRC16 TRAM1 TRAM-1TNRC14

Research Areas for NCOA3/AIB1

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer
Chromatin Research
Transcription Factors and Regulators