Mrc2 Products

Description

MRC2, also known as C-type mannose receptor 2, is a 1,479 amino acid protein that is 167 kDa, plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands, may be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface, and may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. Disease research is currently being studied with relations to MRC2 and breast cancer, aortic aneurysm, prostate cancer, progression of osteoarthritis, prostatitis,s, schizophrenia, tuberculosis, immunodeficiency, and hepatitis. Interactions with this protein have shown to involve NDEL1, IL10, TGFB1, TGFB2, TGFB3, and UBC in antigen processing-cross presentation, cross-presentation of soluble exogenous antigens (endosomes), adaptive immune system, class I MHC mediated antigen processing & presentation, immune system, phagosome, and tuberculosis pathways.

Bioinformatics

Entrez	9902 Human
Uniprot	NP_006030 Human Q9UBG0 Human
Product By Gene ID	9902
Alternate Names	CD280 antigen CD280C-type mannose receptor 2 CLEC13EUPAR-associated protein ENDO180C-type lectin domain family 13 member E Endocytic receptor 180 KIAA0709FLJ35911 Macrophage mannose receptor 2 mannose receptor, C type 2 UPARAPendocytic receptor (macrophage mannose receptor family) urokinase plasminogen activator receptor-associated protein Urokinase receptor-associated protein Urokinase-type plasminogen activator receptor-associated protein