MLL5 Products

Description

MLL5 is a divergent member of the Drosophila Trithorax related SET and PHD domain containing chromatin regulators that are involved in the regulation of transcriptional "memory" during differentiation. Human MLL5 is located on chromosome 7q22, that is frequently deleted in myeloid leukemias. Inactivation of the Mll5 gene in mice results in a reduction in the average representation of hematopoietic stem cells, and in functional impairment of long term hematopoietic repopulation potential under competitive conditions. Overexpression of the protein also inhibits cell cycle progression.

Bioinformatics

Entrez	311968 Rat 55904 Human 69188 Mouse
Uniprot	AAH62583.1 Human Q8IZD2 Human
Product By Gene ID	55904
Alternate Names	EC 2.1.1.43 FLJ10078 HDCMC04P histone-lysine N-methyltransferase MLL5 KMT2EFLJ14026 Lysine N-methyltransferase 2E MGC70452 myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila) Myeloid/lymphoid or mixed-lineage leukemia protein 5