MEKK3 Products

Description

MEKK3 is a Ser/Thr protein kinase belonging to the MAP/ERK kinase kinase family (1). Closely related to MEKK2, MEKK3 is expressed in a multitude of tissues. MEKK3 directly regulates SAPKs and ERKs pathway via SEK and MEK1, respectively but not the p38 pathway (2) and is also involved in the NF-kB pathway (3). MEKK3 as well as MEKK2 bind, phosphorylate and activate MEK5 through their PB1 domain (4). hKSR-2 (human kinase suppressor of ras-2) has been shown to regulate the activity of MEKK3 (5).

Bioinformatics

Entrez	4215 Human
Uniprot	NM_002401 Human NP_002392.2 Human NP_976226 Human Q99759 Human
Product By Gene ID	4215
Alternate Names	EC 2.7.11.25 MAP/ERK kinase kinase 3 MAPK/ERK kinase kinase 3 MAPKKK3MEKK 3 MEK kinase 3 MEKK3 mitogen-activated protein kinase kinase kinase 3

Research Areas for MEKK3

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cancer
Immunology
Innate Immunity
Protein Kinase