MED7 Products

Description

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Two transcript variants encoding the same protein have been found for this gene.

Bioinformatics

Entrez	9443 Human
Uniprot	NM_004270 Human NP_001094286 Human NP_004261 Human NP_004261.1 Human O43513 Human
Product By Gene ID	9443
Alternate Names	Activator-recruited cofactor 34 kDa component Cofactor required for Sp1 transcriptional activation subunit 9 cofactor required for Sp1 transcriptional activation, subunit 9 (33kD) cofactor required for Sp1 transcriptional activation, subunit 9, 33kDa CRSP33CRSP complex subunit 9 CRSP9hMED7 mediator complex subunit 7ARC34 mediator of RNA polymerase II transcription subunit 7 MGC12284 RNA polymerase transcriptional regulation mediator subunit 7 homolog Transcriptional coactivator CRSP33